(In The Routledge Handbook of Philosophy and Psychology of Forgiveness, edited by Glen Pettigrove and Robert Enright) This chapter discusses forgiveness conceived as primarily a volitional commitment, rather than an emotional transformation. As a commitment, forgiveness is distal, involving moral agency over time, and can take the form of a speech act or a chosen attitude. The purpose can be a commitment to repair or restore relationships with wrongdoers for their sake or the sake of the relationship, usually by forswearing (...) one’s hostile attitudes toward a particular wrongdoing; the commitment may also be to oneself for one’s own sake, to be a person with a virtue of forgivingness. It can be incident-specific, that is, a response to a particular occasion of harm, or a forward-looking disposition, an aim to cultivate the habit of being a forgiving person in advance. The enabling conditions of forgivingness as a virtue may be more basic master virtues including integrity and humility, motivations that also underpin commitments to be unforgiving, so this chapter concludes with some careful consideration of the ethics of unforgivingness to others, and the commitment to be unforgiving of oneself. (shrink)

The precarious rights of senior citizens, especially those who are highly educated and who are expected to counsel and guide the younger generations, has stimulated the creation internationally of advocacy associations and opinion leader groups. The strength of these groups, however, varies from country to country. In some countries, they are supported and are the focus of intense interest; in others, they are practically ignored. For this is reason we believe that the creation of a network of all these associations (...) is essential. The proposed network would act as a support for the already-existing policies of the United Nations’ High Commission for Human Rights, of independent experts, and of the Global Alliance for the Rights of Older People. All three have long ago recommended the creation of a recognized instrument for uniting presently scattered efforts. The proposed network, therefore, will seek to promote the international exchange of relevant expertise, and it will reinforce the commitments and actions that single countries are currently taking to meet these objectives. For example, informative public events can be organised to promote particular support initiatives and to provide an opportunity for new members of the network to be presented. The network will promote health for senior citizens, disease prevention, senior mobility, safe free time for seniors, alimentary education, protection against new risks and dangers, as well as equity in the services necessary for seniors to adopt new information and communication technologies. In the case of retired academic members, the network will promote equality with respect to continuing use of digital technologies (particularly email), continuing access to research libraries, and the guaranteed ability for seniors to fund their own research programs and to deliver free seminars. (shrink)

El sufismo del Sahel posee una gran riqueza simbólica. Las elaboradas cosmologías del sufismo akbariano, en el que se inspira el neo-sufismo, se entremezclan con tradiciones milenarias donde el genio (ǧinn) y el ángel (malāk) conviven con los humanos como otrora lo hacían los espíritus naturales y los ancestros. Este texto esboza, desde el trabajo de campo y las fuentes escritas, una aproximación a una lectura simbólica de las relaciones entre humanos, ángeles y genios en el sufismo de la etnia (...) pular y, en concreto, en la experiencia y la narrativa del maestro sufí senegalés Thierno Ḥassan Dem. -/- The elaborate cosmologies of Akbarian Sufism, in which neo-Sufism is inspired, are interspersed with millenary traditions where the genius (ǧinn) and the angel (malāk) coexist with humans as once the natural spirits and ancestors did. This paper outlines, from the field work and the written sources, an approach to a symbolic reading of the relations between humans, angels and geniuses in the Sufism of the Fulani people. This study focuses, mainly, in the experience and narratives of the Senegalese Sufi master Thierno Ḥassan Dem. (shrink)

It is recognized that Buddhadharma schools are markedly ontologically, epistemologically, and semantically nominalist. Regardless of that, when it comes to the use of the term “consciousness”, there is still a tendency in some Western circles to understand Buddhism in a solipsist or monist way. To this purpose, I argue that the general expression “consciousness” from Buddhadharma texts must be understood according to traditional nominalist Buddhist semantics and theory of entities. In the end, I briefly mention some arguments and viewpoints – (...) defending the plurality/diversity of consciousness – of some Buddhist Dzogchen scholars and masters. (shrink)

To try to understand Nietzsche’s conception of Christianity is to try to understand his conception of morality, or to try to analyze, dissect, and diagnose the forces and the relation of forces that underly it, or permeate it. These forces characterize not only the reality as Nietzsche considers it, but also the dynamic of his own writing, thought, and perspective. This is the reason why we can affirm that Nietzsche’s thought and writing are essentially, intrinsically, paradoxical. Indeed, the Nietzschean text (...) unfolds as what constantly resists and escapes the order of discourse as such, which means that it would be a frustrating undertaking to seek a key that discloses and explicates the plurality of meanings that engender and determine the development of his writing. Paradoxically, Nietzschean thought reveals itself only to the extent that it is masked, reread, repeated, rewritten, and stripped of all attempts to master it. In other words, it progresses through a continuous intermingling of forces and, consequently, of values, interpretations, and significations that are unceasingly overcoming and surpassing each other. (shrink)

This paper is a new defense of type-B materialism against Jackson’s knowledge argument (1982) inspired by the Kantian main opposition between concepts and sensible intuitions. Like all materialists of type B, I argue that on her release from her black-and-white room, Mary makes cognitive progress. However, contrary to the so-called phenomenal concept strategy (henceforth PCS), I do not think that such progress can be accounted for in terms of the acquisition of new concepts. I also reject Tye’s recent account of (...) Mary’s cognitive progress as the acquisition of a “thing-knowledge.” What is crucial is not the Russellian opposition between knowing things and knowing truths but rather the Kantian opposition between conceptual and nonconceptual representations of the same thing (property). Mary’s phenomenal knowledge is here accounted for as the result of the cooperation of her newly acquired nonconceptual representation of the same phenomenal redness (the same thing) she had a conceptual representation before. As that new nonconceptual representation carries information about the same physical property she already represented but is now coded in analog rather than in digital form (Dretske, 1981), that nonconceptual representation can be accounted for in physical terms as Chalmers’s Master argument requires. Nevertheless, that representation can account for Mary’s cognitive progress since it carries information coded in analog form, something that the imprisoned she could never possess. (shrink)

Examining the significance of the General’s enlightenment in the Platform Sutra, this article clarifies the fundamental role that emotions play in the development of one’s spiritual understanding. In order to do so, this article emphasizes that the way to enlightenment implicit in the story of the General and the Master involves first granting negative emotions a means for productive expression. By acting as a preparatory measure for calming the mind and surrendering control over it, human passions become a necessary, (...) antecedent condition to wisdom—a conclusion that this article argues is a major, and sometimes underappreciated, lesson embedded in the teachings of the Sixth Patriarch. (shrink)

Le mémoire de Master 2. Soutenu en 2012 à Paris VIII sous la direction de Ch. Ramond. A study of Spinoza's account of "singular things" in the Ethics along with the classic French literature on the subject. -/- TABLE DES MATIÈRES: INTRODUCTION GENERALE (p. 3 – 4) PREMIERE PARTIE : DE LA NATURE DE DIEU AUX CHOSES SINGULIERES (p. 5 – 97) INTRODUCTION (p. 5 – 16) : DU RAPPORT DE L’INFINIMENT INFINI ET DU FINI. Pourquoi l’Éthique commence par (...) l’infiniment infini (Dieu). De l’immanentisme spinoziste. Abrégé de la réalité des choses singulières. Que celles-ci sont « en autre chose » et que cet autre est Dieu. Rôle important de la « cause de soi » dans l’ontologie spinoziste. Description de la démarche à suivre. PREMIER PAS (p. 17 – 39) : DE LA « CAUSE DE SOI ». Sur la définition de la « cause de soi ». De la méthode géométrique, et de la raison pour laquelle l’Éthique commence avec cette définition d’un Ens causa sui. Comment la notion de la « cause de soi » fonde l’idée de Dieu. Du monisme intégral chez Spinoza. De « l’esprit » du spinozisme et du déterminisme absolu. Du dédoublement de Dieu. INTERMEDE (p. 40– 60) : DE LA PROPOSITION 16 ET DES MODES INFINIS. Derechef, du dédoublement de Dieu, et en particulier, du renversement de la situation théorique du qualitatif et du quantitatif dans le système. Rôle de la Proposition 16 dans le système. Comment celle-ci scelle le passage de l’Ens causa sui à l’Ens effectus sui. Pourquoi I 16 est controversé. Comment I 16 nous apprend que Dieu ne produit nécessairement tout qu’à condition de produire de l’intelligible. De l’intellect de Dieu. Des modes, et des modes infinis en particulier. À propos du souci néoplatonicien. SECOND PAS (p. 61 – 91) : DE L’ESSENCE ET L’EXISTENCE DES CHOSES EN ÉI. Les Propositions 24 et 25. Comment Dieu scinde les essences des existences. Que toute chose finie est par essence dans un rapport intime avec sa cause infinie et verticale. Le Scolie de la Proposition 25. Sur la démonstration de la définition des « choses particulières ». Sur la controverse de l’attribut. Les Proposition 26 et 28. Comment les choses existent. De la causalité horizontale et de l’indéfini. Analyse de la notion de l’infini. De l’impossibilité de comprendre totalement l’existence d’une chose. Ce qui veut dire « Deus quatenus ». FIN DE LA PREMIERE PARTIE (p. 92 – 97) : DE LA NATURE NATURANTE ET LA NATURE NATUREE. Analyse du Scolie de la Proposition 29. De l’asymétrie du dédoublement de la Nature. Du salut spinoziste. DEUXIEME PARTIE : DE L’UNITE DES CHOSES SINGULIERES (p. 98 – 153) INTRODUCTION (p. 98 – 102) : DU RAPPORT DE L’ESSENCE A L’EXISTENCE. Ce qui se passe lorsqu’on quitte une Partie de l’Éthique. De ce qu’on a vu dans notre Première Partie. De la causalité verticale et de la causalité horizontale. Comment les essences peuvent-elles retrouver les existences, et vice versa. Description de la démarche à suivre. PREMIER PAS (p. 103 – 127) : DE L’ESSENCE Sur la définition d’une « essence ». De sa positivité. Que ce qu’un individu est par essence n’est que ce qu’il peut comprendre. De la Proposition 8, de son Corollaire et de son Scolie. Que l’existence de l’essence d’une chose ne se confond pas avec l’existence de la chose elle-même. Contre l’idée que les essences sont des choses « possibles ». Sur la notion des « grandeurs intensives » et sur la notion du « profondeur » chez Spinoza. SECOND PAS (p. 128 – 149) : DU CONATUS A LA PHYSIQUE Sur le concept du conatus. Du fait qu’il est l’essence actuelle d’une chose. Qu’on ne peut pas distinguer entre notre puissance ou effort pour persévérer dans l’être et l’être dans lequel nous nous persévérons. Du dynamisme introduit par le biais du conatus. Du rapport du quantitatif et du qualitatif, de l’idée des instants d’éternité, et du problème des essences qui sont instantanées. De la « petite physique » dans la Deuxième Partie de l’Éthique. Sur ses enjeux théoriques. Sur le matérialisme de Spinoza. De la définition de l’Individu comme rapport fixe de mouvement et de repos. Des corps simples, et que pour toute chose existante il n’est pas donné une essence. De la définition des choses singulières, et encore de la mutabilité ontologique de celles-ci. FIN DE LA DEUXIEME PARTIE (p. 150 – 153) : DE LA FINITUDE Sur l’Axiome de la Quatrième Partie de l’Éthique. Que certains rapports de mouvement et de repos en remplacent d’autres. Sur la raison pour laquelle tout rapport ne peut pas coexister. Que la destructibilité vient du biais de l’Étendue, et en particulier, du problème de l’espace. Que la chose singulière véhicule une tension entre la partie et le tout, et encore, du salut spinoziste. CONCLUSION GENERALE (p. 154 – 157) ENGLISH SUMMARY (p. 158 – 159) BIBLIOGRAPHIE (p. 160 – 165) TABLE DES MATIERES (p. 166 – 169). (shrink)

van Els, Paul. "De Meester spreekt nu eindelijk Nederlands" (The Master Finally Speaks Dutch). Review of Confucius: de Gesprekken, by Kristofer Schipper. Filter 22, no. 1 (2015): 55–56.

El tema central de esta tesis de maestría en filosofía de la ciencia es el de la naturaleza de la persistencia a través del tiempo, en el contexto de nuestras mejores teorías físicas acerca del espacio-tiempo. Este problema involucra uno de los conceptos centrales en nuestra comprensión científica del mundo físico, a saber, el concepto de tiempo. La forma usual en que se plantea el problema de la persistencia involucra ciertas nociones que están conectadas con la física, pero estos supuestos (...) rara vez suelen ser formulados de manera explícita, empero, extrapolar las disputas filosóficas en torno a la naturaleza de la persistencia al contexto de espacios newtonianos, galileanos y relativistas (minkowski) no es una tarea trivial. Estos espacios son algunos de los espacios fundamentales donde ocurre la dinámica de los objetos físicos en física clásica. -/- En esta investigación he perseguido diferentes objetivos que vinculan el problema de la persistencia, las diferentes tesis que buscan resolver el problema y las estructuras espacio-temporales postuladas nuestras mejores teorías físicas: -/- 1. Articular el problema de la persistencia, así como varios supuestos de metafísica y filosofía de la ciencia indispensables para plantear la discusión, así como para formular mi solución. 2. Introducir a detalle las diversas estructuras-espacio temporales que, en nuestras mejores teorías de física, albergan a los objetos materiales persistentes. 3. Introducir herramientas formales que permitan analizar la relación de todo-parte en contextos temporales (mereología), así como las propiedades formales de la relación de ubicación que mantienen los objetos materiales con las regiones espacio-temporales. 4. Reformular las posiciones, con estas herramientas, en las estructuras espacio-temporales previamente mencionadas. 5. Ofrecer una serie de argumentos que favorecen lo que más adelante caracterizo como “perdurantismo de ubicación”, desde dos posiciones metafísicas: el unitismo, la tesis de que el tiempo y el espacio son aspectos de una sustancia más fundamental, el espacio-tiempo y el supersustantivismo, la tesis de que el espacio-tiempo y sus propiedades son suficientes para dar soporte a una ontología realista en el caso de nuestras mejores teorías físicas. -/- De esos cinco puntos me ocupo, en ese orden, en los cinco capítulos de esta investigación, con el capítulo V siendo mi contribución original a la literatura especializada sobre el tema. En los primeros capítulos (I, II) el enfoque es en presentar una serie de posiciones y asunciones estructurales en filosofía y física. En los capítulos intermedios (III, IV), hay también una presentación de posiciones filosóficas dominantes en la literatura (Balashov, 2010; Gibson y Pooley, 2006; Gilmore, 2008, 2014; Calosi y Fano, 2015; Saucedo, 2011) que acompañan a una discusión de elementos formales de mereología y postulados estructurales de las teorías naturalizadas de persistencia a través del tiempo. El capítulo V, que es mi contribución original a la discusión filosófica, integra todo lo discutido en los capítulos anteriores en una serie de argumentos que presento en favor del perdurantismo de ubicación. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 42.2 (2004) 219-220 [Access article in PDF] Jack Zupko. John Buridan: Portrait of a Fourteenth-Century Arts Master. Notre Dame: University of Notre Dame Press, 2003. Pp. xix + 446. Cloth, $70.00. Paper, $40.00. What does the name "John Buridan" call to mind? For many, including medievalists, not much at all—at best, perhaps, a set of apparently unrelated ideas: nominalism; an impetus theory (...) of projectile motion; and a peculiar account of the will (although "Buridan's ass," the indecisive donkey caught between two equally appetizing bales of hay, is not found in Buridan's writing). In correcting this ignorance—an injustice to arguably the most famous and influential philosopher of the early-to-mid-fourteenth century—the temptation might have been to articulate Buridan's "positions" on "the big questions," allowing readers to fit Buridan into received categories. Thankfully, the present work, the first book-length study of Buridan in any language, resists this temptation. The John Buridan that emerges from Jack Zupko's skillful "exercise in philosophical portraiture" doesn't serve to simply fill gaps in our awareness of the historical record, but to enlighten and challenge our understanding of the practice of philosophy and the study of its history.Zupko emphasizes throughout that Buridan was a teacher, a master of arts in Paris. Buridan's pedagogical concerns help make sense of his central work in logic. As the basis for his arts lectures, Buridan chose Peter of Spain's Summulae Logicales, but in commenting on Peter, Buridan moves beyond creative exegisis to comprehensive renovation. Buridan (c. 1300-c. 1361) naturally wanted to accommodate terminist or via moderna supposition theory; but more importantly, he wanted a logic text that would set out a general plan of philosophical inquiry, "a compendium of methods, a 'how-to' book for the philosopher" (135). Buridan thus designed his own Summulae de Dialectica as a new authoritative logic text, and Zupko persuasively argues that its "nominalism" should be understood as less a set of doctrines in theoretical logic, than a program of logical practice, an education in logic as the ars artium, the universal intellectual tool.Zupko's portrait of "Buridan's vision of the philosophical enterprise" is thus appropriately divided into two parts. The first summarizes Buridan's method as described in the individual treatises of his Summulae. The second displays the method in practice, rehearsing and evaluating some of Buridan's arguments on various subjects. Many scholars will gravitate first to the latter part, where Zupko offers important interpretations and clarifications of Buridan's views. In these chapters, Zupko helps us to appreciate, among other things: how the problem of universals served to help Buridan define the scope of philosophy (ch. 10); the philosophical modesty of Buridan's account of the intellectual soul's presence in the body (ch. 11); the relationship between Buridan's epistemology and the skepticism of his Parisian contemporary Nicholas of Autrecourt (ch. 12); the sense in which Buridan is an "empiricist," viz an epistemic naturalist and reliabilist (ch. 13); how Buridan regarded moral psychology as applied physics, treating virtue as a kind of impetus (ch. 14); how Buridan's account of freedom can be regarded as a "perfection" of Thomistic intellectualism (ch. 15).Throughout these discussions, Zupko always keeps in sight his larger purpose of illustrating Buridan's conception of philosophical inquiry. Zupko makes much of the fact that [End Page 219] Buridan never wrote as a theologian, remaining his entire career in the arts faculty, where he wanted logic to organize secular inquiry. As Zupko notes, in this way Buridan's scholastic project seems to prefigure the "modern." But Buridan seems modern in another way as well. As Zupko points out in his "Introduction," though a cleric, Buridan never joined a religious order, so that his ideas developed independently of the Franciscan and Dominican traditions. He was, then, a teacher without a tradition—at least without deliberate allegiance to tradition, although he was in many ways the product of traditional scholastic intellectual discipline.Perhaps this... (shrink)

Consider a game of blind chess between two chess masters that is recorded in some standard chess notation. The recording is a representation of the game. But what is the game itself? This question is, we believe, central to the entire domain of social ontology. We argue that the recorded game is a special sort of quasi-abstract pattern, something that is: (i) like abstract entities such as numbers or forms, in that it is both nonphysical and nonpsychological; but at the (...) same time, (ii) through its association with specific players and a specific occasion, tied to time and history. We discover other abstract patterns of this sort especially in the domains of law and commerce. This essay draws on the work in social ontology, we of Hernando de Soto and of John Searle to develop an ontology of the social world based on an analysis of the peculiar interdependence between quasi-abstract patterns and their representations in documents of different sorts. (shrink)

Lenin Pantoja Torres nació el 11 de diciembre de 1988 en Lima (Perú). Ha realizado estudios literarios en pregrado y posgrado en la Universidad Nacional Mayor de San Marcos. Cuenta con un máster en Innovación Pedagógica y Gestión de Centros Educativos por EUCIM Business School de España. Asimismo, es magíster en Educación con mención en Políticas y Gestión de la Educación por la Universidad de San Martín de Porres (Lima, Perú). Con respecto al ámbito laboral, se ha desempeñado como tutor (...) y docente de Lenguaje en la Universidad Peruana de Ciencias Aplicadas (UPC), institución en la que laboró por más de siete años y aprendió unas óptimas técnicas de redacción. (shrink)

Adoptando una revitalización de la tradición marxista en los Estudios Sociales de Ciencia y Tecnología (STS) y en la filosofía contemporánea, mi trabajo se ocupa de la emergencia de la colapsología en Francia y Bélgica, Europa y el mundo, sus tensiones constituyentes con el campo hegemónico de los societal collapse studies. La tesis realiza un seguimiento minucioso de la colapsología y sus profetas fundacionales, el ingeniero agrónomo y Doctor en Biología, Pablo Servigne, y el administrador ambiental de empresas y Máster (...) en Ciencias Holísticas, Raphaël Stevens, en su intento retórico de constituir un nuevo campo. En el primer capítulo, realizo un diálogo crítico y ensamble de dinámicas y funcionamientos de los campos, estudios de retóricas e ideologías de las ciencias, literaturas especializadas sobre hegemonías de riesgos y catástrofes, reconsiderando los catastrofismos y las finitudes del capitalismo. En el segundo capítulo, en un rango temporal de 2015-2024, en siete momentos analizo los mecanismos de emergencia y reconocimiento, hegemonía y contrahegemonía de los actores colapsólogos, sus repertorios discursivos de catástrofes y disciplinas, con el desglose de su hipótesis fuerte del colapso civilizatorio de la modernidad termo industrial. En las conclusiones, realzo el interés reflexivo del campo mundial STS y la filosofía hacia los campos de estudios catastrofistas. Valiéndome del caso emergente de la colapsología, evidencio los resultados centrales conseguidos y las conexiones con diagnósticos de estados de riesgo y estados de ánimo cultural, tanto de las tecnociencias actuales y sus expertos, como de los públicos, las clases sociales y las sociedades, respecto a la crisis epocal de la civilización capitalista contemporánea. -/- Adopting a revitalization of the Marxist tradition in Science and Technology Studies (STS) and contemporary philosophy, my work addresses the emergence of collapsology in France and Belgium, France and the world, its constituent tensions with the hegemonic field of societal collapse studies. The thesis carefully monitors collapsology and its founding prophets, the agronomer engineer and Doctor in Biology, Pablo Servigne, and the environmental business administrator and Master in Holistic Sciences, Raphaël Stevens, in their rhetorical attempt to constitute a new field. In the first chapter, I carry out a critical dialogue and assembly of dynamics and functioning of the fields, studies of rhetoric and ideologies of sciences, specialized literature on hegemonies of risks and catastrophes, reconsidering catastrophisms and the finiteness of capitalism. In the second chapter, in a time range of 2015-2024, in seven moments I analyze the mechanisms of emergence, recognition, hegemony and counter hegemony of the collapsological actors, their discursive repertoires of catastrophes and disciplines, with the breakdown of their strong hypothesis of the civilizational collapse of thermo-industrial modernity. In the conclusions, I highlight the reflexive interest of the world STS field and philosophy towards the fields of catastrophist studies. Using the emerging case of collapsology, I demonstrate the central results achieved and the connections with diagnoses of risk states and cultural moods, both of current technosciences and their experts, as well as of the public, social classes and societies, regarding the epochal crisis of contemporary capitalist civilization. (shrink)

In 1601 certain Jesuits in Alcalá de Henares defended the following thesis: «It is not by faith that we confess that this man, for example, Clement VIII, is Pope.» During 1602 this fact became known in Rome and the Pope urged that the Spanish Inquisition imprison these Jesuits. To defend themselves, they alleged that the thesis was not unusual among scholars, indicating the names of several authors who defended it, among them, the eminent professor emeritus of Salamanca Domingo Báñez. However, (...) he convened an academic act in Valladolid on July 2, 1602 to show that his position was not such. Shortly thereafter, the Jesuits held another event in the same town to challenge the thesis of their coreligionists, underscoring their opposition even more than Báñez. New, partly unknown material on the subject is copied in these pages: the letters from the nuncio to the head of the Vatican State, with annotations written by the Pope, and a letter from the King of Spain to his ambassador; the complete text of the theses defended by Báñez and by the Jesuits in July 1602, as well as two unpublished letters from Báñez on the occasion of his act, one to the master general of his Order and the other to the Pope. (shrink)

In Philosophy, it is well known that of the total faculty population, the proportion of women is significantly lower than men. This disproportion is odd for a discipline within the humanities; these numbers seem more compatible with what is found in STEM (Science, Technology, Engineering, Mathematics) careers. These proportions are in turn a product of the low female presence that exists from the previous levels of academic training in philosophy. What happens in the case of the philosophy student body? For (...) example, the report presented by BeeBee and Saul (2011), on women in philosophy in the United Kingdom, in the period 2008 and 2009, points out that in the first degrees of academic training, in the bachelor's degree, women occupy 45% of the student population, in the master's degree 38% and in the doctorate 35%. Thus, "it is notable that there is a reduction in the proportion of women from the bachelor's degree to the doctorate [...]. This has as a consequence that at the professional level women holding positions as professors represent only 19%" (BeeBee & Saul, 2011, p. 11). Recently, Torres González (2018), based on European Union studies, points out that in Spain, with respect to gender disparity in students, "the data yield as a result masculinized studies, where, contrary to what happens in the branch of the humanities to which it [philosophy] belongs, males outnumber females by 28 percentage points" (2018, p. 328). This disparity is reflected in philosophy at the professional level, "the indicators of vertical segregation show a reinforced glass ceiling, which presents one of the worst data of hierarchical discrimination in the university: the percentage of female professors in philosophy is 12% compared to 21% of female professors in higher education" (Idem). Although it is a fact that there are fewer women than men studying philosophy and, therefore, fewer women than men working professionally in this discipline, we do not yet have possible explanations for this phenomenon of gender disparity in the student body in philosophy. In some cases, even if the number of women entering the philosophy degree program is already low, the number of women graduating is even lower, which indicates that there is attrition along the way; the initial numbers of women entering the program tend to decrease by the time they graduate. Thus we come to the question that is the subject of this paper: What causes female students to drop out of the philosophy program? In this article we answer this question from the philosophy of science and supported by local empirical data, so we do not give a complete or even less exhaustive answer. We review two explanatory models that purport to answer the question of why there are fewer women in philosophy, both formatively and professionally. These are the Different Voices Model (DVM) and the Perfect Storm Model (PSM); we opt for the latter and give reasons for it. Regarding the empirical aspect of our research, our source of statistical data belongs to the undergraduate program in philosophy at the Facultad de Estudios Superiores Acatlán-UNAM, Mexico (FES Acatlán), obtained in the framework of the SWIP-Analytic Mexico workshops. Our analysis of these data shows that even when female students have better GPAs than male students and take fewer subjects while enrolled, female students graduate less than male students in the FES Acatlan degree program. (shrink)

Many pages have been written about the relationship between Mircea Eliade and I.P. Culianu, but the subject is still open for the future. The master-disciple relationship they established during the time was often scattered with moments of tension. Anyway, every time we remember the name Culianu, it will stand beside his master’s name from Chicago, whose place he took after the latter’s disappearance. The way in which Christianity is analyzed in their work occupies a certain place. And thus, (...) because along with a few other situations, their visions regarding this theme seem contradictory. These pages want to be a preamble of work about the Christian values in Mircea Eliade’s thinking, which we have in progress. (shrink)

In this paper I would like to give a brief account of self-creation in Nietzsche’s work, by employing some of Michel Foucault’s ideas. For Nietzsche, life should be lived like “a work of art without an author”. This phrase may sound at first strange, but it makes sense if we take a look at Foucault analysis on authorship. The author is not something given, a transcendental and external agent, but something that emerges in the process of writing. In the same (...) way, the subject is not an autonomous and absolute entity, but something that emerges in the process of subjectivation. If we understand this, then we can move forward to investigate some of Nietzsche’s most famous, yet intriguing concepts. Assuming this new account of the subject, ideas like “become who you are”, the dichotomy “master/slave”, “eternal recurrence of the same” etc. will bear new meanings that can give new answers to the old question: “How should one live?”. (shrink)

The article examines the principles of Giancarlo De Carlo’s design approach. It pays special attention to his critique of the modernist functionalist logic, which was based on a simplified understanding of users. De Carlo′s participatory design approach was related to his intention to replace of the linear design process characterising the modernist approaches with a non-hierarchical model. Such a non-hierarchical model was applied to the design of the Nuovo Villaggio Matteotti in Terni among other projects. A characteristic of the design (...) approach applied in the case of the Nuovo Villaggio Matteotti is the attention paid to the role of inhabitants during the different phases of the design process. The article explores how De Carlo’s “participatory design” criticised the functionalist approaches of pre-war modernist architects. It analyses De Carlo’s theory and describes how it was made manifest in his architectural practice—particularly in the design for the Nuovo Villaggio Matteotti and the master plan for Urbino—in his teaching and exhibition activities, and in the manner his buildings were photographs and represented through drawings and sketches. The work of Giancarlo De Carlo and, especially, his design methods in the case of the Nuovo Villaggio Matteotti can help us reveal the myths of participatory design approaches within the framework of their endeavour to replace the representation of designers by a representation of users. The article relates the potentials and limits of De Carlo’s participatory design approach to more contemporary concepts such as “negotiated planning”, “co-production”, and “crossbenching”. The article also intends to explore whether there is consistency between De Carlo’s theory of participation and its application. (shrink)

Os minerais possuem uma influência direta em diversos processos fisiológicos no organismo animal e, mesmo com tamanha importância, por vezes são negligenciados pelos produtores para seu fornecimento para os animais. Este estudo teve como objetivo avaliar o desempenho reprodutivo de rebanhos de bovinos, caprinos e ovinos em 8 propriedades rurais nas cidades de Sanharó, Pesqueira, Arcoverde, Belo Jardim e São Bento do Una através da adição de suplemento mineral e mistura múltipla aos animais de forma a atender suas necessidades básicas (...) para mantença e reprodução. Foram avaliados os desempenhos de 4 touros e 25 vacas, 3 bodes e 50 cabras e 4 carneiros e 48 ovelhas em diferentes propriedades, avaliando como a adição de um suplemento mineral específico da espécie impacta de forma positiva nos índices reprodutivos avaliados que foram taxa de cio, taxa de serviço, taxa de concepção, taxa de fertilidade, taxa de prenhez, taxa de perdas gestacionais, taxa de natalidade e taxa de mortalidade. O experimento teve duração de 2 anos e pôde-se avaliar cerca de 2 partos nas vacas e, mais ou menos, 3 partos em cabras e ovelhas. Os dados foram computados e avaliados estatisticamente no Excel para conferir se os índices reprodutivos melhoraram em função da adição de minerais na ração dos animais. Conferiu-se que houve diferença significativa entre todos os índices avaliados, ou seja, a adição de minerais na ração dos animais melhora a eficiência reprodutiva de machos e fêmeas de animais ruminantes, sendo de suma importância sua disponibilização de forma correta para alcançar bons índices reprodutivos na fazenda na busca pela obtenção de neonatos que poderão ser comercializados. -/- REFERÊNCIAS BIBLIOGRÁFICAS ASTRO, G. B. A importância da adição de minerais na dieta de caprinos e ovinos no Agreste de Pernambuco. Trabalho de Conclusão de Curso (Técnico Subsequente em Agropecuária) - IFPE Campus Belo Jardim. Belo Jardim, 2023. 44 p. BALAMURUGAN, B. et al. Mineral an important nutrient for efficient reproductive health in dairy cattle. Int. J. Environ. Sci. Technol, v. 6, n. 1, p. 694-701, 2017. Barros NN, Bomfim MAD. Mistura múltipla para caprinos e ovinos. In: Anais VIII PECNORDESTE – Seminário Nordestino de Pecuária, 8; 2004; Fortaleza, Brasil. Fortaleza: FAEC, 2004. p. 50-57. BERCHIELLI, T. T.; PIRES, A. V.; OLIVEIRA, S. G. (Eds.). Nutrição de ruminantes. Jaboticabal: Funep, 2011. COTTA, T. Minerais e vitaminas para bovinos, ovinos e caprinos. Viçosa: Aprenda Fácil, 2001. DANTAS, C. C. O.; DE MATTOS NEGRÃO, F. Funções e sintomas de deficiência dos minerais essenciais utilizados para suplementação dos bovinos de corte. UNICiências, v. 14, n. 2, 2010. DA SILVA EIC. A água na nutrição animal. 1ª ed. Recife, PE: Instituto Agronômico de Pernambuco, 2023. DA SILVA, Emanuel Isaque Cordeiro. Cálculos de consumo e digestibilidade de alimentos e nutrientes para ruminantes. Revista Universitária Brasileira, v. 1, n. 3, 2023. DA SILVA, Emanuel Isaque Cordeiro. Concentrados e Rações Para Cabras em Lactação. 2022. DA SILVA, Emanuel Isaque Cordeiro. Efeitos da raça e do manejo nutricional sobre as características de qualidade da carcaça e da carne em ovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia da Reprodução de Bovinos Leiteiros: Aspectos Básicos e Clínicos. Emanuel Isaque Cordeiro da Silva, 2022. DA SILVA, Emanuel Isaque Cordeiro. Formulação de ração para caprinos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação de ração para ovinos. 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Avaliação de Suplemento Mineral Para Caprinos. Instrução Técnica Para o Produtor Rural de Pernambuco, v. 3, n. 1, p. 1-4, 2023. DA SILVA, Emanuel Isaque Cordeiro. Formulação e fabricação de rações para ruminantes. 1ª ed. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Fabricação de Rações Para Ruminantes: Bovinos, Caprinos e Ovinos. 2021. DA SILVA, Emanuel Isaque Cordeiro. Manejo Reprodutivo e Índices Zootécnicos em Gado de Leite. 2023. DA SILVA, Emanuel Isaque Cordeiro. Métodos de Formulação e Balanceamento de Rações para Bovinos. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Nutrição e Suplementação Mineral de Bovinos de Corte. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Opções de concentrados para vacas em lactação no Semiárido. 2022. DA SILVA, Emanuel Isaque Cordeiro. Relação e Efeitos Bioquímico-nutricionais Sobre os Cistos Ovarianos em Vacas. DA SILVA, Emanuel Isaque Cordeiro. Relação e Efeitos Bioquímico-nutricionais Sobre os Transtornos do Ciclo Estral em Vacas. DA SILVA, E. I. C. Suplementação e formulação de sal mineral e mistura múltipla para bovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. DE MENDONÇA JÚNIOR, A. F. et al. Minerais: importância de uso na dieta de ruminantes. Agropecuária Científica no Semiárido, v. 7, n. 1, p. 01-13, 2011. DE PAULA SILVEIRA, L. Suplementação mineral para bovinos. Medicina Veterinária e Zootecnia, v. 11, n. 5, p. 489-500, 2017. FADLALLA, I. M. T. The Interactions of Some Minerals Elements in Health and Reproductive Performance of Dairy Cows. New Advances in the Dairy Industry, 2022. FERGUSON, J. D. Nutrition and reproduction in dairy cows. Veterinary clinics of North America: Food animal practice, v. 7, n. 2, p. 483-507, 1991. GALVANI, D. B.; BOMFIM, MAD. Mistura múltipla para caprinos e ovinos: nova fórmula dispensa adaptação. 2015. HAENLEIN, G. F. W.; ANKE, M. Mineral and trace element research in goats: A review. Small Ruminant Research, v. 95, n. 1, p. 2-19, 2011. KAWAS, J. R.; ANDRADE-MONTEMAYOR, H.; LU, C. D. Strategic nutrient supplementation of free-ranging goats. Small Ruminant Research, v. 89, n. 2-3, p. 234-243, 2010. KESSLER, J. Mineral nutrition of goats. In: Goat nutrition, v. 46, p. 104-119, 1991. LOPES, H. O. S. Suplementação de baixo custo para bovinos: mineral e alimentar. 1998. MANERA, D. B. et al. Mineral mixtures from solid salt residues for lambs. Revista Brasileira de Zootecnia, v. 43, p. 485-491, 2014. MASTERS, D. G. Practical implications of mineral and vitamin imbalance in grazing sheep. Animal Production Science, v. 58, n. 8, p. 1438-1450, 2018. MORAES, S. da S. Importância da suplementação mineral para bovinos de corte. Campo Grande, MS: Embrapa Gado de Corte, 2001., 2001. NICODEMO, M. L. F. et al. Minerais na eficiência reprodutiva de bovinos. 1ª ed. São Carlos: Embrapa Pecuária Sudeste, 2008. 50 p. NIX, J.. Trace minerals important for goat reproduction. Sweetlix Livestock Supplement System, 2002. NOGUEIRA, É. et al. Nutrição aplicada à reprodução de bovinos de corte. In: MEDEIROS, S. R. et al. (Eds.). Nutrição de bovinos de corte: fundamentos e aplicações. 1ª ed. Brasília: Embrapa, 2015. p. 143-156. PASA, C.. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2010. PEIXOTO, P. V. et al. Eficiência reprodutiva de matrizes bovinas de corte submetidas a três diferentes tipos de suplementação mineral. Pesquisa Veterinária Brasileira, v. 23, p. 125-130, 2003. PRADA, F. Influência da nutrição animal na reprodução de touros: revisão. Revista de Educação Continuada do CRMV-SP, v. 8, n. 1, p. 68-76, 2005. ROGÉRIO, M. C. P. et al. Manejo alimentar de caprinos e ovinos nos trópicos. Veterinária e Zootecnia, v. 23, n. 3, p. 326-346, 2016. SARTORI, R.; GUARDIEIRO, M. M. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. SHARMA, M. C. et al. Mineral nutrition and reproductive performance of the dairy animals: a review. The Indian Journal of Animal Sciences, v. 77, n. 7, 2007. SILVA, D. C. et al. Importância do uso de minerais na dieta de bovinos reprodutores. Vet. zootec, p. 38-52, 2018. SOUZA, G. V. Suplementação de minerais na reprodução de bovinos. Trabalho de Conclusão de Curso (Graduação em Zootecnia) - UFG. Jataí, 2014. 32 p. TEIXEIRA, J. C. Nutrição de ruminantes. Lavras: FAEPE, 1992. UNDERWOOD, E. J.; SUTTLE, N. F. Los minerales en la nutrición del ganado. 3ª ed. Zaragoza: Acribia, 2003. VALADARES FILHO, S. C. et al. (Eds.). Tabelas brasileiras de composição de alimentos para ruminantes. 1ª ed. Viçosa: UFV, 2015. VALENTIM, J. K. et al. Fatores nutricionais aplicados à reprodução de ruminantes. UNICIÊNCIAS, v. 23, n. 2, p. 77-82, 2019. VASCONCELOS, F. F. Suplementação mineral no manejo reprodutivo ovino. Dissertação (Mestrado em Medicina Veterinária) - Centro de Ciências Rurais, UFSM. Santa Maria, 2012. 50 p. VÁZQUEZ-ARMIJO, J. F. et al. Trace elements in sheep and goats reproduction: a review. Tropical and Subtropical Agroecosystems, v. 14, n. 1, p. 1-13, 2011. VELLADURAI, C.; SELVARAJU, M.; NAPOLEAN, R. E. Effects of macro and micro minerals on reproduction in dairy cattle a review. International Journal of Scientific Research in Science and Technology, v. 2, n. 1, p. 68-70, 2016. YASOTHAI, R. Importance of minerals on reproduction in dairy cattle. International Journal of Science, Environment and Technology, v. 3, n. 6, p. 2051-2057, 2014. (shrink)

This article transcribes three unpublished manuscripts by Domingo Báñez. The first is a review on the opuscule by Chrysostom Javelli on predestination. Báñez believes that this writing is Pelagian and advances several arguments which he will later use against Luis de Molina and the Molinists. The second is the last preserved writing by Báñez: a letter to the Master General of the Dominicans where he mentions his hope of seeing an end to the dispute on grace and free will. (...) The third is the account of Báñez’s death including his last words, in which he mentions the famous controversy de auxiliis. (shrink)

In the traditional sense, a work of art creates an illustration of the outside world, or of a certain text or doctrine. Sometimes it is considered that such an illustration is not literal, but is an interpretation of what is visible, or an interpretation of a certain literary or ideological message. It can also be assumed that a work of art creates its own visual world, a separate story or a separate philosophical statement. The Parc de La Villette represents the (...) last of these possibilities: it is a philosophical statement that develops the premises derived from poststructuralist philosophies and the philosophy of deconstruction. The uniqueness of its being status, however, is that it does so not only at the level of the theoretical assumptions, but also through its functioning as an active philosophical work. This means that a park is a happening philosophy. Its activity, however, does not refer only to the present tense, but is also an attempt to penetrate the future, all otherness and impossibility. This kind of activity assumes that the work, in a sense, does not yet fully exist, but is also still produced in the processes of its interpretation. The theoretical foundations of the park included texts by Bernard Tschumi, in which he questioned traditional ways of creating a work of architecture, postulating in return the use of a long series of negations, which were comparable to the crisis of metaphysics characteristic of contemporary philosophy. It is therefore no coincidence that the publication containing Tschumi’s theoretical text on Parc de La Villette was accompanied by an essay by Jacques Derrida developing some of the architect’s concepts. The next step in integrating philosophy into the process of park design was a series of discussions between Peter Eisenman and Derrida, who completely moved the creation of the park into the world of thoughts, without accentuating the need for their realization in the material reality. The main topic of these discussions was the problem of the chôra, which was taken up by later commentators and used to interpret the park as a work in which the philosophy of the beginning is manifested relating to issues of politics, morality and religion. The park was therefore interpreted as a space of invention within the scope of creating new rules of functioning of the community and democracy. Thinking about the political future may, however, exceed the horizon of ordinary expectations. Although philosophical thought is always connected with contemporary problems and metaphysics sometimes intertwines with current politics, yet at the same time the customs of philosophy also include crossing horizons and thinking about absolute otherness and impossibility. Initially, the chôra, différance, Absolute Otherness (tout autre) and the Impossibile were concepts of pure philosophy of atheistic character, but with the further development of the discussion, more and more theological motifs began to emerge. One of the reasons for this phenomenon was the fact that radical negations of all being, which were contemplated in contemporary philosophy (by Heidegger and Derrida, among others), had previously been manifested in negative and apophatic theologies (by Master Eckhart, among others). Also the category of the “Other”, taken from Emmanuel Levinas, was clearly connected with the thought about God. A further reason for connecting the chôra with the theological thought was the interest in the philosophy of deconstruction expressed by some theologians. Caputo in particular managed to persuade Derrida to participate in discussions on the current status of religion. In the late period of Derrida’s writing, further statements on religious topics appeared. All these reasons led to posing a question about the identity of the chôra and God. Although there were no satisfactory conclusions on this issue, the discussion was also important to create an interpretation of the park as a place of worship. The chôra, representing, according to Plato, the preoriginal emptiness is the place of every beginning, but it turns out that it is not neutral to the being created in it. The chôra deposits itself in every being as an irremovable beginning that interferes with its stability. The chôra, therefore, forces us into a palintropical movement, but it also turns out to be a pure compulsion, an erring necessity and a fundamental force from which, in the human perception, motifs useful to the individual and to the community are extracted. All definitions of this force, including its anthropomorphisation, are formulated in such a way that they allow for building private and collective morality upon them. Such definitions are changed depending on variable political situations. It is difficult to determine whether in the processes of changes in the formulation of “God’s names” any essential value is retained, which is not subject to change. The current definitions of the chôra (God?), which can be found, for example, in the philosophy of Caputo, stress that she is a combination of various and contradictory forces. This characteristic inherits much of Plato’s concept, reminds us of Master Eckhart’s views on Gottheit and, at the same time, is not unfamiliar to Tschumi, whose essays were an apologia of contradictions. The current concept of chôra, transferred into the sphere of politics, is the praise of social diversity and the protection of the difference from the forces of order. In the Parc de La Villette, the future community and democracy were elevated as a system of safe existence of individuals in all their singularity. The park is a temple of a future community in which individual beings have nothing in common. (shrink)

St. Anselm is a master of philosophical prose. His writings on God, truth, and free will are models of clarity born of unflagging concern for argumentative precision. He is especially adept at using analogies to cinch his readers' understanding of these recondite matters. Who could forget the light shed upon the concept of existence by the Painter Analogy in the Ontological Argument or how his River Analogy illumines the unification of the Holy Trinity? Such intellectual insights could only be (...) gifts of the Holy Ghost for the edification of Holy Mother Church. I shall discuss here the three splendid analogies that St. Anselm draws in De Concordia in order to reconcile grace and free will, fostering an understanding of co-operation according to which divine assistance must accentuate, rather than nullify, exercises of human freedom. Central to my discussion is The Father of Scholasticism's four-fold distinction between a power, its exercises, the effects of those exercises, and opportunities to bring about those effects. (shrink)

The inclusion of De astrologia in the Lucianic corpus has been disputed for centuries since it appears to defend astrological practices that Lucian elsewhere undercuts. This paper argues for Lucian’s authorship by illustrating its masterful subversion of a captatio benevolentiae and subtle rejection of Stoic astrological practices. The narrator begins the text by blaming phony astrologers and their erroneous predictions for inciting others to “denounce the stars and hate astrology” (ἄστρων τε κατηγοροῦσιν καὶ αὐτὴν ἀστρολογίην μισέουσιν, 2). The narrator assures (...) readers that he, the knowledgeable astrologer, will correct for the “stupidity and laziness” (ἀμαθίῃ καὶ ῥαθυμίῃ, ibid.) that bring about false predictions. The narrator’s credibility quickly decays when he attempts to recast Orpheus, Bellerophon, Icarus, Daedalus, and a host of other mythological figures as Greek astrologers. Lucian’s audience would expect such far-fetched interpretations of myth from the stereotypical Stoic philosopher, a character lampooned elsewhere in the Lucianic corpus. (shrink)

The history of the relationship between Christian theology and the natural sciences has been conditioned by the initial decision of the masters of the "first scientific revolution" to disregard any necessary explanatory premiss to account for the constituting organization and the framing of naturally occurring entities. Not paying any attention to hierarchical control, they ended-up disseminating a vision and understanding in which it was no longer possible for a theology of nature to send questions in the direction of the experimental (...) sciences, as was done in the past between theology and many philosophically-based thought-systems. Presenting the history of some hinge-periods in the development of the Western-world sciences, this book first sets out to consider the conceptual revolution which has, in the 20th Century, related consciousness, physical laws and levels of organization, in order to show that a new chance existed then for theology. This discourse was invited to revise its language to open it up to the quest for meaning which we find on the periphery of the project of the experimental sciences. The Century-old reflection on the foundations of probability had prepared the ground for the introduction of the concept of information, at first linked to an effort aimed at maximizing the efficiency of electromagnetic communications. Taking the full measure of the questions that information theory poses to the biological sciences, this work attempts to identify the areas of convergence setting the stage for general systems theory, while it also tries to identify the insufficiencies of this recent vision and to highlight the questions left unanswered. Re-reading some of the traditional proofs of God's existence from the order of the world, relying on some pioneering insights of Ludwig von Bertalanffy and Norbert Wiener, the author brings those proofs and insights in contact with the fascinating initial project of cybernetics and the elements of a "mythical" nature which, from its inception, it could never entirely eliminate. This book ends with the confrontation between the conceptually most extended regulation factors in the history of Western thought. It articulates the poetic utopia concerned with an immediate grasp of the world in its "deictic" character with the concurrent one aimed at the domination over matter and energy expressed by technology's driving rational utopia. (shrink)

María José Rincón González nació en Sevilla (España) y reside en República Dominicana desde 1992. Es miembro de número de la Academia Dominicana de la Lengua (ADL) desde el 2011 y directora del Instituto Guzmán Ariza de Lexicografía. Asimismo, es miembro correspondiente de la Real Academia Española (RAE) y miembro del consejo asesor de Fundéu Guzmán Ariza. Con respecto a su formación superior, es doctora en Filología por la Universidad Nacional de Educación a Distancia (UNED) y máster en Lexicografía por (...) la Universidad de Sevilla y la UNED. Ha participado en congresos internacionales y ha contribuido en las ediciones de diccionarios del idioma español. Entre sus publicaciones de artículos, se encuentran las que pertenecen al Diario Libre y el Boletín de la Academia Dominicana de la Lengua, entre otros textos, tales como “La antroponimia femenina dominicana (1945-1995)” (2002), “El Diccionario de la lengua” (2013), “Presentación del Diccionario de americanismos de la ASALE” (2013), “Variantes dialectales del léxico dominicano en el Diccionario de americanismos” (2016), “La lematización de variantes gráficas en el Diccionario del español dominicano” (2017) y “El Diccionario de criollismos, primer diccionario dominicano” (2020). De igual modo, ha publicado en libros y capítulos de libros. Entre ellos se encuentran el Diccionario del español dominicano (2013), “El nacimiento de un nuevo diccionario: el Diccionario del español dominicano” (2017) y De la eñe a la zeta (2019). (shrink)

The Shadow of God in the Philosopher’s Garden. The Parc de La Villette in Paris in the context of the philosophy of chôra I Bernard Tschumi’s project of the Parc de La Villette could have won the competition and was implemented thanks to the political atmosphere that accompanied the victory of the left-wing candidate in the French presidential elections in 1981. François Mitterand’s revision of the political programme and the replacement of radical reforms with the construction of prestigious architectural objects (...) and urban assumptions in the French capital gave Tschumi a unique opportunity to realise ideas that polemicised with traditional forms of social life, questioned the basic principles of architecture and included architectural work in the philosophical disputes over the issues of metaphysics. Tschumi’s theoretical assumptions put forward during the design of the Parc de La Villette highlighted the questions of conflict between the main components of the project and suggested that the intensification of differences was analogous to Jacques Derrida’s creation of the concept of différance. It was this philosopher who in a special commentary to Derrida’s project also introduced the concept of maintenant, which aimed at demonstrating that the architect’s polemical inclinations remain in a hidden balance with his inclinations to affirmation of architectural principles. During the discussion between Derrida and Peter Eisenman, who was to take part in the design of the Parisian park, the concept of the chôra was also put forward, which in the course of the debate led to an additional confusion of architectural and philosophical problems. II In the period from the Antiquity to the Renaissance, the dialogue Timaeus was the most frequently commented work of Plato. At present, the most frequently discussed is the issue of the chôra included in it, which aroused fascination among philosophers, researchers of rhetoric, religion, feminism, but also architecture. The work on the chôra also influenced the development of the interpretation of the Parc de La Villette, among which the topics related to the beginning and the change were highlighted. In early uses of the word chôra in Greek, as in Homer’s 18th Book of Iliad, it meant both dancing and a place to dance. On this occasion, it can be seen that it is not possible to determine which phenomenon took precedence in the creation of the name. It cannot be denied, however, that the word concerned a specific movement, as if circular and returning to an indefinable beginning. Despite gaining more and more general meanings, the word chôra has retained its connection with the dance of people on the threshing floor, the dance of bees (choros meliton) or the dance of stars (choros astron). In Timaeus, the chôra is a space filled with movement with an effect similar to shaking the sieve to husk the grain: it separates similar elements from the dissimilar ones. The juxtaposition of the Parc de La Villette and the chôra already at this stage leads to the suggestion that the park was treated by the architect as a place of dynamic changes leading to the establishment of new social solutions. In his statements, the architect confirmed that the park was to be a space of new politics and ethics. The book by Julia Kristeva La Révolution du langage poétique contributed to the spread of the belief that works of art can play a role as factors of political revolution. In this work, the author put forward the thesis that the chôra is a kind of space, the character of which has a destructive influence on attempts to conclude language games. The chôra gives beginning to words, but at the same time, by leaving a trace of this beginning it forces us to renew their meanings. The chôra understood in this way, turns out to be an irremovable beginning, to which one has to return all the time. Kristeva found manifestations of the chôra’s activity in avant-garde French poetry, to which she attributed the role of a mediator between criticism of metaphysics and aspirations for social change. The chôra, violating the language, introduces some voids into it, as if traces of the abyss, which direct the consciousness towards understanding the necessity of political changes. The Parc de La Villette was to pursue similar objectives in the city space. In his essays, Tschumi considered the problems of creating spaces that would give rise to a radical democracy. The proposed rebellious spaces should have the characteristics of a void, in which contradictory forces would occur as forms of pure activity. The means of achieving this goal was to concentrate contradictions and make them visible. The Parc de La Villette was supposed to collect differences as indelible and at the same time by showing them it was supposed to raise awareness of the social world as a conglomerate of differences. Saturation of the space of the park with subversive values results from the character of this space suppressed in the consciousness, as well as from the social diversity which has not been taken into account so far. The main contradictions contained in space relate to the division that exists between its presentation as a mental problem and a sensual one. The park was the deliberate creation of a place that transcends such a division and creates a separate space for negotiation between architectural theories and its practical applications. The purpose of the park was to become a place of future events, which would not hide their conflicting character coming from diversity of both space and society. The method of composition usually aimed at achieving a harmonious whole has been replaced by Tschumi with a system of juxtaposition of non-coherent elements or those resulting from variations and transformations. Tschumi did not seek direct influence on politics in the Parc de La Villette, but made room for thinking about the possibilities of the future. He introduced problems rather than showed solutions to them. The task of the park was to put the principles of architecture into a kind of vibration that would inspire users to participate in the new community. III Tschumi believes that the quality of architecture depends on the theoretical factor it contains. Such a view led to the creation of architecture that would achieve visibility and comprehensibility only after its interpretation. On his way to creating such an architecture he took on a purely philosophical reflection on the basic building block of architecture, which is space. In 1975, he wrote an essay entitled Questions of Space, in which he included several dozen questions about the nature of space. The questions he formulated could be regarded as analogous to the situation in the philosophy of the time, in which the interest in questioning the most obvious forms of understanding the world and intellectual categories increased. The research on space is an area common to many fields of natural sciences, humanities and artistic creation, but it also deals with other problems, such as issues of experience. The concept of space-time continuum proposed by Hermann Minkowski drew attention to the identity of time and space with the events taking place. Probably regardless of the postulates of physicists commenting on Albert Einstein’s discoveries, also in philosophy it increased the importance of the concept of the event which became dominant in Martin Heidegger’s latest work Contributions of Philosophy: Of the event. Furthermore, Tschumi’s reflections on space entered into relation with the problem of experience, which aroused the interest of a group of French philosophers trying to assimilate Georges Bataille’s concept of “inner experience”. Both Tschumi and Derrida referred to Bataille because his views could be used not only to modify the concept of the subject, but also to change the understanding of what constitutes the area of architecture. The discussion on experience has led to the recognition that the subject is not sovereign, but actually a form of what is on their outside. Such insights make it possible to treat the area of the Parc de La Villette as existing mainly when it is organised by its users. The decisive features of the park are its assumptions, according to which it is a variety of active void that leads to agreeing new social relations with it. The park does not force to participate in already existing moral or political communities, but tries to move into an unknown future in which the scope of free functioning of individuals will be increased. Doubts about the principles of functioning of the individual self and its discovery as a whole composed of non-coherent parts, as well as its dependence on its own depth full of disordered forces, influenced the understanding of architecture as a set of contradictions whose source is a fundamental void anticipating the empty phenomenal space. The use of this phenomenal void in architecture, as well as the rejection of the whole and unity, had a specific political purpose and drew its inspiration from political analyses. In the Parc de La Villette, metaphysics and politics were brought closer together because the philosophy of void was used to create new conditions for community action. It can be argued that the source of this philosophy was the perception of errors in existing societies dependent on the shortcomings of traditional metaphysics. Spacing (espacement) was one of the key terms in Derrida’s philosophy, which was also combined with the concepts of différance and chôra. The study of the nature of space, especially its transition from the level of pure possibility to the level of sensual phenomenon, also contributes to understanding how well designed space can have an impact on its audience. This explanation is based on Tschumi’s assumption that the space of the Parc de La Villette contradicts the integrating approaches and instead exposes contradictions, but it does so in a way that combines incompatible properties into a single piece of architecture. The specificity of such integration is similar to the invention of a musical phrase, which is an ideological message: moral and political. Such a thesis may raise doubts, however, if both the clearly adopted assumptions and those deduced from the work allow for their logically ordered presentation then to a limited extent it may be assumed that the work has achieved a connection between a specific philosophy of space and its practical application. Derrida combined the problem of spatiality with the problem of transcendental imagination in the philosophy of Immanuel Kant, who in the first version of Critique of Pure Reason assumed that pure imagination precedes the appearance of time and space, even in their transcendental forms. The imagination in such a situation can be described as a factor activating time and space, which indicates what function is played by movement in this activity. This leads us to recognize that the ultra originary source of pure forms of sensual intuition is movement, which in early Greek philosophy was identified with void and its lack of resistance to phenomena occurring in it. Derrida’s philosophy in search of a certain super-transcendental source of time and space pointed to différance which, like void or the chôra, does not have material features or even any other form of being. Différance is the primary cause of the disruption of motionlessness and the introduction of activity into motionless time and space, thus its activity can be described as spacing (espacement). Derrida’s discoveries in this respect are not entirely original, because Georg Wilhelm Friedrich Hegel already pointed out when examining the present that it is primarily a differential relation (differente Beziehung), which, being seemingly neutral, influences the present with supernatural force and makes it unidentifiable with itself. Differente Beziehung must similarly influence the originary space, negating its initial character by multiplying its divisions and expanding its boundaries. Différance acts by revealing contradictions wherever there is apparent undifferentiation. Tschumi, composing the Parc de La Villette as a variety of void and a set of incompatible layers, followed the rules of différance or the chôra: he made void visible together with its saturation with contradictions. If space can be considered to be the result of the activity of difference, such activity has a certain regularity, which influences the behaviour of its observers. Differences or contradictions fall into a certain rhythm, which can be considered a manifestation of transcendent order. The problem is that what can be considered the source of such order, namely the logos or God, is partly disorder and error. According to descriptions contained in Timaeus, the world is a combination of forces that drive to order with forces of erroneous necessity that resounds in every order and forces it to return to disorder. Derrida denied the possibility of understanding différance as a theological value, even if it were a negative or apophatic theology, but no categorical denial could be perfect. The assumption that différance or the chôra are not endowed with any substance properties cannot deny their activity, and thus a certain force. Already since Democritus, philosophy has multiplied the names of such a force and the contradictory variety of its manifestations, never forgetting also the necessity for reason to withdraw from the possibility of giving its correct characteristics. Such a withdrawal may be interpreted as an expression of respect and, in certain situations, as a cult of the force that precedes reasonableness. The Parc de La Villette, which is an artistic divagation about the contradictions and forces behind them, can be considered as a place of their sublimation, and therefore as a variation of the temple of what differs from order and disorder. IV In the texts that presented the theoretical assumptions of the Parc de La Villette, Tschumi used a large number of terms that contradicted not only the traditional principles of composing architecture, but also negated the rules of social order and the foundations of Western metaphysics. Tschumi’s statements, which are a continuation of his leftist political fascinations from the May 1968 revolution, as well as his interest in the philosophy of French poststructuralism and his collaboration with Derrida, prove that terms such as “disruption”, “dissociation”, “disfunction”, “disjunction” and “dispersion” not only referred to architectural problems but also applied to political criticism and the deepest foundations of thinking itself. His collaboration with Derrida manifested itself primarily in the publication La Case Vide: La Villette 1985, in which the architect’s design drawings and texts explaining his concepts related to the Parc de La Villette were accompanied by an extensive essay by Derrida, which included theoretical problems taken up by Tschumi in a philosophical context. Architectural and philosophical issues were also combined during seven discussion meetings organised by Eisenman, invited by Tschumi to collaborate on the design of the Parc de La Villette. Eisenman, who, like Tschumi, invited Derrida to participate in the design of the park and also led to the publication of Chora L Works: Jacques Derrida and Peter Eisenman, in which his ideas were confronted with Derrida’s philosophical text. In this case, Derrida’s essay was not a direct commentary on the architect’s concepts, but rather a reflection on the question of the chôra presented by Plato in Timaeus. During the discussion and in his essay, Derrida pointed out that the chôra is a component of the created world, yet it does not belong to it, but precedes it. The originality of the chôra is so radical that she also precedes all the factors of creating the world, including ideas and the Demiurge. Thus athesis appeared in the metaphysics of the West that the chôra is a form of active abyss, in relation to which all beings are secondary, both those perfect (as ideas or God) and those created, such as the world, things, people or language. This leads to the conclusion that the chôra does not exist, because all existence is a derivative of the chôra. Nor could the chôra be described, since it is a form of developing a space that is preceded by a lack of space characteristic of the chôra. Derrida intended the chôra to be an instance with an exceptional degree of transcendentalism, an anti-metaphysical instance, but also an a-theological one. However, this attempt failed, both in the field of secular philosophy and in the field of theology. Derrida’s characteristics of the chôra to strengthen its transcendentalism and negation of metaphysics had to be expressed in a language that immediately produces new concepts and a new metaphysics that reproduces the categories of the beginning, the origin or the foundation known from earlier philosophical traditions. All forms of criticism of metaphysics are also inspired by negative, apophatic and mystical theology. The undermining of many concepts of permanent meaning and the introduction of new concepts of unstable meaning, characteristic of the philosophy of deconstruction, had many features of originality, but it was directed towards problems whose solutions repeat, with the use of new vocabulary, the findings known in culture since Democritus. Thus, if apophatic philosophy can be regarded as deconstruction avant la lettre, then deconstruction itself in its late versions began to take on the features of a new religion. The exchange of inspiration between theology and deconstruction was manifested in a series of scientific conferences and publications in which Derrida’s philosophical concepts were interpreted within the scope of religious thought. Theological threads began to be found in such concepts of deconstruction as différance or the chôra, while at the same time Derrida himself undertook in his philosophy to study problems such as the Other (L’Autre) or the Impossible (Impossible), which belonged to newer theological traditions. As a consequence of the new problems, the deconstruction became closer to the features of a new religion. Philosophy, at least from Kant’s time, has tried to create a system that would take over from religion the tasks of setting moral and political goals. Similarly, Derrida has directed his interest towards the problems of democracy and ethics, which would enable their renewal. Attempts to create a new religion (cleared of old metaphors), a new community or a new democracy bring problems and threats which may be no less troublesome than the previous systems. All promises of freedom carry with them threats, the greater the more they strive for perfection. The renewal of existential orders, sometimes carried out by means of violent changes, is a certain repetitive feature of human cultures. Deep changes, however, do not protect against the return of both old gods and old demons. Tschumi and Derrida were shaped in their youth by the atmosphere of leftist rebellion against the moral and political limitations of ossified communities and the imperfections of democracy. The ethical theme distinguishes many of their works, including the Parc de La Villette. The opposition to the metaphysical traditions of philosophy and architecture contained in this park was prompted by specific political situations and resulted from bringing political issues to the level of philosophical considerations. Achievements made at the level of pure concepts were then subject to elevation, to a kind of sacralization, which made them religious concepts. The deconstruction reached for the status of the new religion especially when it found its followers and began to generate moral obligations. In the new situation, terms such as the chôra, l’Autre or the Impossible were absolutized and in relation to them a cult and attitude of adoration emerged. The Parc de La Villtette then gained new post-secular meanings, which allow it to be assigned the function of a Temple of Otherness (L’Autre) and Impossible. V In the traditional sense, a work of art creates an illustration of the outside world, or of a certain text or doctrine. Sometimes it is considered that such an illustration is not literal, but is an interpretation of what is visible, or an interpretation of a certain literary or ideological message. It can also be assumed that a work of art creates its own visual world, a separate story or a separate philosophical statement. Parc de La Villette represents the last of these possibilities: it is a philosophical statement that develops the premises derived from poststructuralist philosophies and the philosophy of deconstruction. The uniqueness of its being status, however, is that it does so not only at the level of the theoretical assumptions, but also through its functioning as an active philosophical work. This means that a park is a happening philosophy. Its activity, however, does not refer only to the present tense, but is also an attempt to penetrate the future, all otherness and impossibility. This kind of activity assumes that the work, in a sense, does not yet fully exist, but is also still produced in the processes of its interpretation. The theoretical foundations of the park included texts by Tschumi, in which he questioned traditional ways of creating a work of architecture, postulating in return the use of a long series of negations, which were comparable to the crisis of metaphysics characteristic of contemporary philosophy. It is therefore no coincidence that the publication containing Tschumi’s theoretical text on Parc de La Villette was accompanied by an essay by Derrida developing some of the architect’s concepts. The next step in integrating philosophy into the process of park design was a series of discussions between Eisenman and Derrida, who completely moved the creation of the park into the world of thoughts, without accentuating the need for their realization in the material reality. The main topic of these discussions was the problem of the chôra, which was taken up by later commentators and used to interpret the park as a work in which the philosophy of the beginning is manifested relating to issues of politics, morality and religion. The park was therefore interpreted as a space of invention within the scope of creating new rules of functioning of the community and democracy. Thinking about the political future may, however, exceed the horizon of ordinary expectations. Although philosophical thought is always connected with contemporary problems and metaphysics sometimes intertwines with current politics, yet at the same time the customs of philosophy also include crossing horizons and thinking about absolute otherness and impossibility. Initially, the chôra, différance, absolute otherness (tout autre) and the Impossible were concepts of pure philosophy of atheistic character, but with the further development of the discussion, more and more theological motifs began to emerge. One of the reasons for this phenomenon was the fact that radical negations of all being, which were contemplated in contemporary philosophy (by Heidegger and Derrida, among others), had previously been manifested in negative and apophatic theologies (by Master Eckhart, among others).Also the category of the “Other”, taken from Emmanuel Levinas, was clearly connected with the thought about God. A further reason for connecting the chôra with the theological thought was the interest in the philosophy of deconstruction expressed by some theologians. John Caputo in particular managed to persuade Derrida to participate in discussions on the current status of religion. In the late period of Derrida’s writing, further statements on religious topics appeared. All these reasons led to posing a question about the identity of the chôra and God. Although there were no satisfactory conclusions on this issue, the discussion was also important to create an interpretation of the park as a place of worship. The chôra, representing, according to Plato, the preoriginal emptiness is the place of every beginning, but it turns out that it is not neutral to the being created in it. The chôra deposits itself in every being as an irremovable beginning that interferes with its stability. The chôra, therefore, forces us into a palintropical movement, but it also turns out to be a pure compulsion, an erring necessity and a fundamental force from which, in the human perception, motifs useful to the individual and to the community are extracted. All definitions of this force, including its anthropomorphisation, are formulated in such a way that they allow for building private and collective morality upon them. Such definitions are changed depending on variable political situations. It is difficult to determine whether in the processes of changes in the formulation of “God’s names” any essential value is retained, which is not subject to change. The current definitions of the chôra (God?), which can be found, for example, in the philosophy of Caputo, stress that she is a combination of various and contradictory forces. This characteristic inherits much of Plato’s concept, reminds us of Master Eckhart’s views on Gottheit and, at the same time, is not unfamiliar to Tschumi, whose essays were an apologia of contradictions. The current concept of chôra, transferred into the sphere of politics, is the praise of social diversity and the protection of the difference from the forces of order. In the Parc de La Villette, the future community and democracy were elevated as a system of safe existence of individuals in all their singularity. The park is a temple of a future community in which individual beings have nothing in common. (shrink)

Many theories about the teaching of logic and critical thinking take for granted that theoretical learning, the learning of formal rules for example, and its practical application are sufficient to master the tools taught and to take the habit of using them. However, this way of teaching is not efficient, a conclusion supported by much work in cognitive science. Approaching cognition evolutionarily with dual-process theories allows for an explanation of these insufficiencies and offers clues on how we could teach (...) critical thinking and logic more efficiently. In this article, we want to present this approach and explore these leads in order to make some pedagogical recommendations and lay the foundations of a framework. We will put forward an example of the application of this research program with philosophy for children. (shrink)

The master's thesis of Dr. Taraneh Javanbakht in philosophy that was published at the Université du Québec à Montréal in 2016 includes her innovations in logic and cognitive sciences as well as some parts of her philosophical system, netism. Her logic, tendential logic, that she introduced and developed and its application in cognitive science were also published in her master's thesis in philosophy.

After almost a decade of study, research, and dissemination in the field of philosophy for children (p4c), the University of the Azores has created a Master’s degree in Philosophy for Children. While it may appear to be just another university course of study in the academic field of philosophy, we believe that this Master’s is a case study in its own right, as it has allowed us to think about what p4c is capable of when it takes over (...) the university. Not only has the Master’s degree helped shape p4c, but p4c has itself driven the development of the Master’s. Through this process, a different way of existing “within the university” emerges, revealing points worthy of attention that conventional academia does not always value. This article reflects on some of the ideas relating to this process and, without any pretension of establishing rules or claiming to be a finished product, offers some considerations that in our view constitute a turning point for the way people exist within the university. After experiencing a Master’s based upon p4c, neither the university nor philosophy itself can be understood in the same way as before. What is it about p4c, then, that makes it capable of transforming whatever it touches? (shrink)

In this paper we will review the history of Quechua in the Peruvian territory (including the eras of the Inca empire, the viceroyalty, and the republic) and consider the challenges it faces in order to survive from the bicentenary of our republic onwards. I begin by showing that most varieties of Quechua are in a process of extinction and reflect on the causes that may have determined this trend in the republican era. I defend the thesis that it was the (...) progressive increase in opportunities for social mobility in the republic that motivated an increasing adoption of Spanish by Quechua speakers, since such opportunities depended on mastering Spanish. The paper closes by discussing about the possibilities to reverse the trend towards the extinction of Quechua. (shrink)

The literary genesis of Einbahnstraße by Walter Benjamin represents a very special case of the use of the procedures of surrealism in the philosophical-literary production of the author. The process of evolution of thinking that ended up in the writing of this piece is unveiled throughout the present analysis. This is a sign of both waiver and restart; the opening for a new productive dimension in the career of one of the most important —and misunderstood— philosophers of the 20th century. (...) More than enlightening a small master piece of philosophy from a literary perspective, or analyzing a small master piece of literature from the philosophy, what is being problematized here is the division, cultivated or figured throughout the years, between both disciplines. This work is intended to recover what is insoluble from the philosophical-literary labor of Walter Benjamin, besides tracing a possible reconfiguration for an interdisciplinary field of work to come up and contribute in the understanding of the problem called The Retreat of Metaphor by Jacques Derrida. (shrink)

Kearns (2021) reconstructs Berkeley’s (1713) Master Argument as a formally valid argument against the Materialist Thesis, with the key premise the Distinct Conceivability Thesis, namely the thesis that truths about sensible objects having or lacking thinkable qualities are (distinctly) conceivable and as its conclusion that all sensible objects are conceived. It will be shown that Distinct Conceivability Thesis entails the Reduction Thesis, which states that de dicto propositional (ordinary or distinct) conceivability reduces to de re propositional (ordinary or distinct) (...) conceivability. While Kearns (2021) set out to avoid the confusion of a de re claim with a de dicto claim, which Prior (1955) accused Berkeley of, Kearns can be accused of making a similar conceptual confusion. (shrink)

Essays on Aristotle's Sea-Battle, Lazy Argument, Argument Reaper, Diodorus' Master Argument -/- The book is devoted to the ancient logical theories, reconstruction of their semantic proprieties and possibilities of their interpretation by modern logical tools. The Ancient arguments are frequently misunderstood in modern interpretations since authors usually have tendency to ignore their historical proprieties and theoretical background what usually leads to a quite inappropriate picture of the argument’s original form and mission. Author’s primary intention was to draw attention to (...) the complexity of some historical arguments and to the theoretical context in which arguments were created, circulated, developed, and finally tuned. Four well-known ancient arguments – with a common central subject related to the future contingencies problem – are reconstructed from available historical sources: “The Sea Battle”, which is drawn from Aristotle’s treatise De Interpretatione; two arguments, usually ascribed to the Stoics, “The Lazy Argument” and “The Reaper”; “The Master Argument” of the Megarian philosopher Diodorus. Arguments are linguistically and semantically detaily analyzed, formally presented by reflecting some relevant corresponding hypotheses based on physical or logical theories of their ancient authors, and finally covered by appropriate logical tools familiar to a modern reader. Two appendices are added at the closing part of the book. One covering some assumptions relevant for understanding of rival streams in ancient theories of meaning related to the nature of names and naming; the other is devoted to the ancient understanding of logical proposition and attempts to find an adequate Latin translation of the Greek delicate philosophical term “ἀξίωμα”. (shrink)

St. Anselm is a master of philosophical prose. His writings on God, truth, and free will are models of clarity born of unflagging concern for argumentative precision. He is especially adept at using analogies to cinch his readers' understanding of these recondite matters. Who could forget the light shed upon the concept of existence by the Painter Analogy in the Ontological Argument or how his River Analogy illumines the unification of the Holy Trinity? Such intellectual insights could only be (...) gifts of the Holy Ghost for the edification of the Holy Mother Church. I shall discuss here the three splendid analogies that St. Anselm draws in De Concordia in order to reconcile grace and free will, fostering an understanding of cooperation according to which divine assistance must accentuate, rather than nullify, exercises of human freedom. Central to my discussion is The Father of Scholasticism's four-fold distinction between a power, its exercises, the effects of those exercises, and opportunities to bring about those effects. (shrink)

A central passage in Cusset’s essay states: “God, for Sade, is fiction that ‘took hold of the minds of men’. What makes God’s weakness, the impossibility of rationally proving his existence, is precisely what constitutes his strength as fiction. Negated as authority, eliminated as the figure of the almighty father, God is nonetheless everywhere in the Sadean novel: he exists as the fiction principle. Libertines are never done with God because his name represents the power, not of the law, but (...) of the imagination. In showing their contempt for God, libertines reveal their anger against fiction, which does not have the power to prove its own truth: fiction — and Sade chose to write novels, not philosophical essays — is based on the desire for illusion” (119). Sade’s L’Histoire de Juliette, argues Cusset, breaks from his earlier writings in that Juliette has an agency missing from Sade’s previous female characters, and she, unlike earlier characters, breaks through the central Sadean impasse: “her ‘story’ represents the solution through which Sade paradoxically resolves the aporia of libertinage” (120). She is perfectly aware of scientific explanations for phenomena, but, “for the sake of play, Juliette chooses metaphor, and does not try to ‘unveil truth’ entirely. Juliette distinguishes herself from her teachers and masters through her relation to imagination. […] The end of the novel confirms Juliette’s choice of a playful imagination” (123). In short, Juliette is the libertine who breaks the very rules of the libertines by means of resurrecting the sense of play, imagination, and romantic delicacy which her fellow criminals forbid. Cusset concludes: “Sade invites us to read his texts as fictive and humorous texts, and not, as suggested the French feminist Elisabeth Badinter who wanted to censor Sade’s novel, as rational demonstrations inviting readers to commit murder. Juliette’s transformation through the novel allows us to understand why Sade entitled his last long novel L 'Histoire de Juliette. Juliette chooses fiction, without trying to prove its truth; she chooses pleasure, without trying to annihilate every belief, since imaginary belief is a component of pleasure. What Sade tells us with the invention of Juliette is that freedom is the very choice of limit. […] L’Histoire de Juliette is Sade’s critique of pure fiction” (129). (shrink)

In 1601 certain Jesuits in Alcalá de Henares defended the following thesis: "It is not by faith that we confess that this man, for example, Clement VIII, is Pope." During 1602 this fact became known in Rome and the Pope urged that the Spanish Inquisition imprison these Jesuits. To defend themselves, they alleged that the thesis was not unusual among scholars, indicating the names of several authors who defended it, among them, the eminent professor emeritus of Salamanca Domingo Báñez. However, (...) he convened an academic act in Valladolid on July 2, 1602 to show that his position was not such. Shortly thereafter, the Jesuits held another event in the same town to challenge the thesis of their coreligionists, underscoring their opposition even more than Báñez. New, partly unknown material on the subject is copied in these pages: the letters from the nuncio to the head of the Vatican State, with annotations written by the Pope, and a letter from the King of Spain to his ambassador; the complete text of the theses defended by Báñez and by the Jesuits in July 1602, as well as two unpublished letters from Báñez on the occasion of his act, one to the master general of his Order and the other to the Pope. (shrink)

[Encyclopedia entry] Born in Italy in 1225, and despite a relatively short career that ended around 50 years later in 1274, Thomas Aquinas went on to become one of the most influential medieval thinkers on political and legal questions. Aquinas was educated at both Cologne and Paris, later taking up (after some controversy) a chair as regent master in theology at the University of Paris, where he taught during two separate periods (1256-1259, 1269-1272). In the intermediate period he helped (...) establish a studium for his Order in Rome, beginning work on the Summa Theologiae, the masterwork for which he is still well-known. Subsequent to an experience (traditionally, a vision) Aquinas had on the feast of St. Nicholas in 1273, Aquinas intentionally refrained from further work on that text, so that it remained incomplete at the time of his death a year later in 1274. Apart from his own contributions, the Thomistic school – including followers within and without the Dominican Order to which Aquinas belonged – has had profound and far-reaching influence upon the history of legal thought in the West. Many of the classical developments of Thomistic thought are written as commentaries on the Summa Theologiae (hereafter, ST), including the works of Tomasso de Vio (Cajetan) and those of Domingo Banez, Francisco de Vitoria, Bartholome de las Casas, and the other highly influential members of the School of Salamanca who are noteworthy for developing Aquinas’ political and legal thought in the 16th century. Specifically, the ways in which Aquinas synthesized classical political and legal themes around the law, morality, and the common good provided a touchstone for what has come to be called ‘natural law jurisprudence.’ Natural law thinkers, in short, appeal to objective facts about what is good for human beings, and the social or political nature of the kind of creatures that we are, as a standard against which we measure the legal and social institutions created by human institutions. What is crucial here is that facts about human beings as social animals constitute reasons for individuals and groups to act or be structured in certain ways, such that ‘nature’ is the proper source for jurisprudential and political principles. (shrink)

Palestra na XIII Semana de Estudos Clássicos da Feusp (in Os Outros, Os Mesmos - A Alteridade no Mundo Antigo. Galatea/Feusp, 2018).

Aims: The purpose of this study is to identify the factors associated with the academic performance of Grade 10 students during their First Quarter of school as well as the significant correlation between the factors and student academic performance in Mathematics. -/- Study Design: Descriptive Correlation Design. -/- Place and Duration of Study: The study was conducted at Agusan National High School in Cagayan de Or City's East 1 District during the school year: 2022 – 2023. -/- Methodology: The respondents (...) were Two hundred thirty-one (231) students in Grade 10 at Agusan National High School in Cagayan de Oro City's East 1 District. This study used a researcher-made questionnaire that underwent validity and reliability testing and the academic performance of the students. -/- Results: The results showed that students agree with routines related to mastering Mathematics at a high level. Furthermore, there is no correlation between student study habits and Mathematics performance in terms of self-confidence, but there is a substantial positive association between the student's study habits and performance in terms of attitude. The study habits and learning techniques used by students were found to be important determinants of how well they performed in Mathematics. The researcher strongly suggested using the enhancement plan in teaching Mathematics to Junior High school students. -/- Conclusion: Students have a very positive attitude toward their study habits when learning Mathematics. Students felt that studying and learning Mathematics was essential. Students' success and academic growth depend heavily on their Mathematics performance. It is essential for pupils to master and comprehend its concepts. Students' study habits in terms of attitudes have an impact on how they learn Mathematics. (shrink)

English title: Gadamer's interpretation of the Aristotelian Protrepticus. -/- Abstract: The aim of this paper is to present and analyse the main hypotheses of Hans-Georg Gadamer in his 1928 essay Der aristotelische Protreptikos und die entwicklungsgeschichtliche Betrachtung der aristotelischen Ethik, emphasizing the Gadamerian reception of the notions of phrónēsis, hēdonḗ and, to a lesser extent, phýsis. It will be attempted to show that in this early work of Gadamer there is more than a methodological and interpretative debate regarding the Protrepticus (...) and the Aristotelian ethics. Lastly, the paper argues that it is possible to read in the main arguments of this early essay the first intellectual maturation of relevance of Gadamer, expressed in the form of a critical dialogue with his great masters (Paul Natorp, Nicolai Hartmann, Martin Heidegger, Paul Friedländer), departing from the new interpretative possibilities that philology and phenomenology opened to his studies on the ethical-political philosophy of Plato and Aristotle. The theoretical consequences of this early article would have both paved the way of Gadamer’s next theoretical interventions regarding Platonic political philosophy as well as for the future developments of philosophical hermeneutics. /// -/- Resumen: El objetivo de este artículo es presentar y analizar las principales hipótesis de Hans-Georg Gadamer en su ensayo de 1928 Der aristotelische Protreptikos und die entwicklungsgeschichtliche Betrachtung der aristotelischen Ethik, poniendo énfasis en la recuperación gadameriana de las nociones de phrónēsis, hēdonḗ y, en menor medida, phýsis. Se intenta demostrar que en este trabajo temprano de Gadamer hay, en términos metodológicos e interpretativos, más que una discusión con Werner Jaeger con relación al Protréptico y a la ética aristotélica. Finalmente, este artículo sostiene que es posible leer en las principales argumentaciones del ensayo la primera maduración intelectual de relevancia de Gadamer, expresada en forma de diálogo crítico con sus grandes maestros (Paul Natorp, Nicolai Hartmann, Martin Heidegger, Paul Friedländer), a partir de las nuevas posibilidades interpretativas que la filología y fenomenología le abrieron para el estudio de la filosofía ético-política de Platón y Aristóteles. Las consecuencias teóricas de este temprano artículo habrían signado tanto el camino de sus siguientes intervenciones teóricas en tono a la filosofía política platónica como también los futuros desarrollos de la hermenéutica filosófica. (shrink)

This article examines an uncommon materialist argument preserved in late medieval Prague quodlibets by Matthias of Knín (1409) and Prokop of Kladruby (1417). The argument connects the Galenic claim that the human body has the noblest and best-balanced complexion possible with the Alexandrist claim that the human rational soul emerges from such well-balanced matter without any supernatural intervention. Of the various medieval renderings of these claims, John Wyclif’s De compositione hominis is singled out as the most probable source of the (...) argument. Far from attributing plain materialism to Wyclif, the article highlights a semimaterialist position, mentioned in two fifteenth-century De anima commentaries of Prague origin, grafting the immortal spirit postulate onto an Alexandrist-like doctrine of the intellect as educed from the harmoniously complexioned body. Finally, it is argued that this semimaterialist position may not only encapsulate how Bohemian masters read Wyclif, but also be close to Wyclif’s actual anthropological stance. (shrink)

Among the main themes introduced by the Ficinian renovatio platonica, love and beauty are certainly ones of the most outstanding and philosophically relevant for the metaphysical, cosmological and anthropological doctrines they convey. Pupil and recognised successor of Marsilio Ficino, Francesco Cattani da Diacceto is the author of an organic and complex philosophy of love and his contribution is extremely significant amid De amore Renaissance treatises. Cattani’s attitude is twofold and ambiguous: he heavily depends on Pico and on his Commento sopra (...) una canzona de amore, however, he also shows his disapproval to Pico’s positions by quoting and commenting negatively large portions of his texts − always keeping the lid on Pico’s name. In addition to doctrinal dissent there seems to be a certain resentment: maybe it is the attempt to throw Pico’s figure and cultural legacy into the shade and to display himself as the only and worthy successor of Ficino; certainly it is the will to defend his master from Pico’s harsh criticism, a defence that became more compelling with the publication of the Commento in 1519, which probably inspired Cattani’s last and unfinished work, the In Platonis Symposium enarratio. (shrink)

Tradução para o português da "Dissertation on passions", de David Hume. Tradução realizada com base nas seguintes edições: 1. Four Dissertations/ David Hume, edited by John Immerwahr. (Facsimile da edição de 1757 publicada por A. Millar, Thoemmes Press, 1995); 2. A Dissertation on the passions ; The natural history of religion : a critical edition /David Hume; edited by Tom L. Be auchamp. (The Clarendon Edition of the Works of David Hume. Oxford: Ox ford University Press, 2007); 3. The Complete (...) Works of David Hume . 1882-1886, edited by Green T.H. & Grose, T. H. (Edição eletrônica in CD-ROM, Série “Past Masters”. Charlottesville : InteLex Corporation, 1992). A paginação entre // corresponde à paginação da edição de 1757, reproduzida na edição da Thoemmes Prees, 1995, editad a por John Immerwahr. (shrink)

This essay is an inquiry into John McDowell’s thinking on ‘subjectivity.’ The project consists in two parts. On the one hand, I will discuss how McDowell understands and responds to the various issues he is tackling; on the other, I will approach relevant issues concerning subjectivity by considering different aspects of it: a subject as a perceiver, knower, thinker, speaker, agent, person and (self-) conscious being in the world. The inquiry begins by identifying and resolving a tension generated by the (...) very idea of ‘rational animal’: human beings are at the same time natural and rational. Later the inquiry proceeds by considering how McDowell’s notion of ‘second nature’ enables us to be human subjects with many faces. By going through the diagnoses and responses of McDowell, two central problems in modern and contemporary philosophy – the narrow conception of nature and the Cartesian inner space model – are identified and repelled. In Episode N I first urge that we should leave room for a certain notion of ‘world.’ I further argue that mentality has many aspects, and to understand those aspects is to understand the many faces of human subject. In Episode Ⅰ the Aristotelian notion of ‘second nature’ is discussed in order to resolve the tension in the very idea of ‘rational animal.’ Later I reply to some worries about this maneuver, including the objection from Crispin Wright. Hans-Georg Gadamer’s distinction between world and environment is introduced and related to McDowell’s thinking. Episode Ⅱ discusses perception and knowledge; McDowell’s main target – the Cartesian inner space – is introduced and criticized. Barry Stroud’s and Simon Blackburn’s positions are evaluated. Later I connect the main theme of Mind and World to the present context; in particular, I discuss McDowell’s invocation of Donald Davidson and Immanuel Kant. And then I discuss a common accusation of idealism, and Robert Brandom’s accusation of ‘residual individualism.’ Episode Ⅲ concentrates on Saul Kripke’s Wittgenstein, arguing that the master thesis behind the rule-following paradox is a version of the inner space model, and that Kripke’s Wittgenstein is not Wittgenstein. Martin Kusch’s objections are answered; Michael Dummett’s demand of reductionism is rebutted. After this, I turn to Davidson’s ‘no language’ claim, and discuss to what extent McDowell agrees with him. In Episode Ⅳ I evaluate objections from Hubert Dreyfus concerning action and agency. I discuss how Dreyfus and Maurice Merleau-Ponty commit ‘the Myth of the Disembodied Intellect’ identified by McDowell. I answer Michael Ayer’s charge of intellectualism in passing. Later I bring in McDowell’s objections to Derek Parfit on personhood and to Davidson on the mind-body relation. In Episode Ⅴ I focus on consciousness and self-consciousness. McDowell applies his argument against Parfit to Kant, but Maximilian de Gaynesford dissents. I reply to his objections on McDowell’s behalf. I further connect this to McDowell’s attacks on the dualism of scheme and content. This leads to my McDowellian rejection to the existence of qualia, and further brings me to the debate between intentionalism and disjunctivism in the context of the argument from illusion. I argue against Tim Crane’s ways of conceiving issues about intentionalism and the argument from illusion. Varieties of disjunctivism are also discussed. In my Epilogue, I express my worry about McDowell’s notion of ‘self-determining subjectivity.’ According to McDowell, human freedom consists in causations in the space of reason, but as Richard Gaskin points out, a satisfying story of it is yet to be provided. I close this essay with some rough ideas about how to fill in the details of the McDowellian picture. (shrink)

What is distinctive about Lucretius’s version of Epicureanism? The answer might appear to be “nothing,” for two reasons. First, Epicureanism in general is doctrinally conservative, with followers of Epicurus claiming to follow his authority. Second, Lucretius claims to be merely transmitting the arguments of his beloved master Epicurus in a pleasing manner. I argue that these considerations do not prevent De Rerum Natura from presenting a distinct version of Epicureanism. Its arguments in physics are almost certainly drawn from Epicurus (...) himself. But in the examples Lucretius uses to illustrate these arguments, as well as in his descriptions of things like the fear of death and the formation of society, Lucretius delivers unexpected insights into human psychology, ones not clearly present in the other sources we have on Epicureanism. Furthermore, the way in which Lucretius presents his arguments can rightly be considered original philosophically and not just poetically. (shrink)

The paper presents a preliminary estimation of the extent of dissemination of optical texts, ideas, and issues among the masters connected with the Prague faculty of arts in the late 14th and early 15th century. Investigation of this topic, so far rather neglected, is based chiefly on manuscript research. The paper brings evidence that perspectiva was taught in Prague at least since the 1370s. It suggests that investigation of Prague quodlibetal disputations (ca. 1390s – 1410s) and consideration of perspectivist authorities (...) employed in these texts can also shed some light on the issue. However, the paper is mainly devoted to the question on the mechanism of vision disputed by Bohemian arts master John of Borotín (Iohannes de Borotin, 1378 – after 1458) in the quodlibet organised by John Hus in 1411. It is suggested that the single extant exemplar of the question (preserved in the codex Prague, National Library, X.H.18) probably is Borotín’s autograph. The structure and sources of the question are analysed, with the conclusion being that Borotín proposes a compromise between intromission and extramission influenced by John Peckham’s Perspectiva communis. A critical edition of Borotín’s question is appended to the paper. / / / Please note this article is published with Brepols Publishers as a Gold Open Access article under a Creative Commons CC 4.0: BY-NC license. The article is also freely available on the website of Brepols Publishers under this same license. (shrink)

The paper delves into manuscript sources connected with various disputations held at Prague University from around 1390 to 1420 and singles out a set of hitherto unknown quaestiones dealing with the nature of the human intellect and its relation to the body. Prague disputations from around 1400 arguably offer a unique vantage point on late medieval anthropological issues, since they encompass an entanglement of numerous doctrinal influences from Buridanian De anima commentaries to John Wyclif’s theories. The paper delineates several conceptual (...) tensions regarding the nature of the intellect, e.g., between materialism (entailed by the emphasis on the intellect’s inherence in the body) and personal immortality. It presents several strategies Prague masters employed to overcome these tensions. For example, an anonymous participant of the 1409 quodlibet develops the Buridanian distinction between the rationally demonstrable materialist tendency and the indemonstrable “catholic truth” about the intellect both inhering in and separable from the body. On the other hand, Wyclif’s adherents (Jacob of Mies and another anonymous master) postulate an immortal spirit hypostatically united to each human being beside the human soul educed from the potency of the matter. Yet, the boundaries between the doctrinal standpoints in question seem permeable, whereby a rigid definition of antagonistic groups in late medieval Prague intellectual milieu (e.g., Buridanians vs Wycliffites) is rendered ineffective. (shrink)

This article deals with the most relevant philosophical side of Albert the Great’s analysis of alchemy, aimed at clarifying what alchemical transmutation consists in and whether this process can ultimately be accomplished by men. The Dominican master handles the problem differently in the earlier commentary on Lombardus’ Libri Sententiarum and in works like the De mineralibus, in which a more mature idea of the connection between art and nature is developed. In this respect, Albert’s interpretation intersects with Avicenna’s De (...) congelatione, a fundamental text for the Latin medieval debate on alchemy, whose reception has shaped his understanding of the alchemical art. The Dominican master gradually assumes a more lenient position towards the claims of the alchemical process of transmutation, which he explains by resorting to the similitudes between alchemy and medicine and the comparison of artificial transmutation with natural processes such as the generatio ex putrefactione and the natural formation of minerals. (shrink)

HORMÔNIOS E SISTEMA ENDÓCRINO NA REPRODUÇÃO ANIMAL -/- OBJETIVO -/- As glândulas secretoras do corpo são estudadas pelo ramo da endocrinologia. O estudante de Veterinária e/ou Zootecnia que se preze, deverá entender os processos fisio-lógicos que interagem entre si para a estimulação das glândulas para a secreção de vários hormônios. -/- Os hormônios, dentro do animal, possuem inúmeras funções; sejam exercendo o papel sobre a nutrição, sobre a produção de leite e sobre a reprodução, os hormônios desempenham um primordial papel (...) quanto ao funcionamento do animal. -/- Nesse capítulo, o estudante identificará os hormônios relevantes para o controle reprodutivo, suas características e o uso clínico dos mesmos. -/- -/- INTRODUÇÃO -/- A endocrinologia é a ciência que se encarrega do estudo do sistema endócrino: um sistema de comunicação entre as células de um organismo; esse trabalho de comunicação é compartilhado com o sistema nervoso já que ambos sistemas possuem características distintas que lhes permite complementar-se para alcançar uma adequada coordenação das funções. Em algumas ocasiões o sistema nervoso e o sistema endócrino interagem direta-mente na transmissão de uma mensagem, pelo qual se conhece como sistema neuroendó-crino. -/- -/- OS HORMÔNIOS -/- A endocrinologia é a ciência que se encarrega do estudo dos hormônios e seus e-feitos. De maneira tradicional os hormônios são considerados como “substâncias secreta-das em direção a circulação pelas glândulas especializadas, e que exercem uma função sobre um órgão branco”. Essa definição, no entanto, é limitada e imprecisa. É necessário ser mais pontual, já que os hormônios não são produzidos em qualquer célula da glândula, senão nas células específicas. Por exemplo, o hormônio luteinizante (LH) é produzido pelos gonadotropos da adenohipófise e não por qualquer outro tipo de célula hipofisária. Da mesma maneira, falar de um “órgão branco” não é exato, já que os hormônios atuam somente nas células que tenham receptores específicos para esse hormônio, e não outras células do mesmo órgão; logo, falar de uma “célula branca” é mais apropriado que falar de um “órgão branco”. As células brancas do LH no testículo são as células de Leydig e as células brancas do hormônio folículo estimulante (FSH) no mesmo órgão são as células de Sertoli. -/- Mediante o supracitado, uma definição mais apropriada de hormônio é a seguinte: “Os hormônios são reguladores biológicos, produzidos e secretados em quantidades pe-quenas pelas células vivas, que depois de viajar pelo meio extracelular atuam sobre as cé-lulas brancas, onde exercem uma ação específica”. -/- É importante levar em conta que os hormônios somente regulam (estimulam ou inibem) funções que já existem na célula branca. Ademais, os hormônios são extraordina-riamente potentes, pelo qual se requerem quantidades muito pequenas para induzir uma resposta na célula. As concentrações circulantes da maioria dos hormônios estão na ordem de nanogramas (10-9 g) ou pictogramas (10-12 g) por mililitro. -/- Etimologicamente o termo “endócrino” significa “secretar em direção adentro”, já que os hormônios são secretados em direção ao interior do organismo (o sangue ou o espaço intracelular), em diferença das secreções exócrinas (em direção ao exterior), que são secretadas em direção a luz de um órgão, como o intestino no caso das enzimas pan-creáticas. -/- Algumas substâncias, sem deixar de ser hormônios, recebem uma classificação adicional em relação ao seu local de ação, ao tipo de células que lhes produzem, ou a al-guma outra característica. Agora, serão descritas algumas dessas características (figura 1). -/- -/- Parahormônio ou hormônio local -/- A maioria dos hormônios são transportados pela circulação desde seu local de se-creção até a célula branca. No entanto, alguns hormônios exercem seu efeito em células adjacentes aquelas que foram produzidos, ao qual não é necessário seu transporte através da circulação geral. Esse tipo de substâncias são chamadas de parahormônios ou hormô-nios locais, e sua liberação é denominada como secreção parácrina. Um exemplo é a pros-taglandina F2 alfa (PGF₂α), que é produzida no epitélio uterino (endométrio) e provoca as contrações nas células musculares do mesmo órgão (miométrio). Deve-se tomar em conta que a mesma substância poderia se comportar em outros casos como um hormônio clássico, atuando em um órgão distinto ao local de sua produção; é o caso da mesma PGF₂α de origem endometrial quando atua sobre as células do corpo lúteo do ovário, pro-vocando sua regressão. A classificação de uma substância como hormônio ou parahormô-nio não depende de sua estrutura química, senão da relação espacial existente entre a célu-la que o produz e a célula branca. -/- -/- Neurohormônio -/- A maioria dos hormônios são produzidos pelas células de origem epitelial, porém, muitos deles são produtos pelos neurônios, logo denominados como neurohormônios. To-dos os neurônios segregam alguma substância, porém tratam-se dos neurohormônios quando o neurônio que os produz despeja-os diretamente em direção a circulação geral, através da qual chegam aos órgãos para exercer seu efeito, sejam na indução, inibição ou estimulação do mesmo. -/- Esse processo é diferente dos neurotransmissores, os quais também são secretados por um neurônio, mas exercem seu efeito em uma célula adjacente com o qual o neurônio estabelece uma sinapse (neuroma com neurônio, neurônio com célula muscular, neurônio com célula glandular). A classificação de uma substância como hormônio ou como neuro-hormônio não depende de sua estrutura química, senão do tipo de célula que o produz. Uma mesma substância é um hormônio quando ele é produzido por uma célula epitelial e um neurohormônio se é produzido por um neurônio. A ocitocina, por exemplo, é secre-tada na neurohipófise por neurônios hipotalâmicos, nesse caso se trata de um neurohor-mônio, mas também é secretada por células do corpo lúteo dos ruminantes, e se trata nesse caso, de um hormônio. A distinção entre um neurohormônio e um hormônio é um neuro-transmissor, da mesma forma, não depende de sua estrutura química, e sim do local onde é secretado. Por exemplo, a dopamina atua como neurotransmissor quando se libera em sinapse da substância negra do mesencéfalo z mas atua como neurohormônio quando é liberada por neurônios hipotalâmicos em direção a circulação do eixo hipotálamo-hipofisário. -/- -/- Pré-hormônio -/- Em alguns casos, os hormônios são secretados em forma inativa (pré-hormônio), que requer uma transformação posterior para converter-se na forma ativa de hormônio. O angiotensinógeno circulante somente cobrará atividade biológica ao se transformar em angiotensina por ação da enzima renina. Algumas substâncias podem atuar como hormô-nios m alguns casos e como pré-hormônios em outros. A testosterona, por exemplo, atua como hormônio nas células musculares, aos quais possui um efeito anabólico direto. O certo é que para a testosterona induzir a masculinização dos órgãos genitais externos em um efeito macho é necessário que seja transformada previamente em 5α-di-hidrotes-tosterona pela enzima 5α-redutase presente nas células de tecido branco, por onde, nesse caso a testosterona é um pré-hormônio de di-hidrotestosterona. -/- -/- Feromônio -/- Os hormônios são mensagens químicas que comunicam a células distintas dentro do mesmo organismo, embora existam casos aos que requerem uma comunicação quími-ca entre organismos diferentes, em geral da mesma espécie. As substâncias empregadas para esse fim denominam-se feromônios. Essas substâncias devem possuir a capacidade de dispersão sobre o ambiente, pelo que nos organismos terrestres geralmente trata-se de substâncias voláteis, enquanto que os feromônios de organismos aquáticos geralmente são substâncias hidrossolúveis. Embora muitos feromônios possuam uma função sexual ou reprodutiva como é o caso de muitas espécies como a canina em que a fêmea em cio dispersa grandes quantidades de feromônios que são captados de longe pelos machos, todavia esse não é sempre o caso, e eles podem ser utilizados para outros tipos de comunicação, como é o caso dos feromônios utilizados pelas formigas para sinalização da rota em direção a fonte de alimentação. E como as abelhas no sentido de orientação da fonte de pólen até a colmeia. Muitos desses feromônios podem ser artificializados, isto é, elaborados pelo homem em laboratório para o estudo ou manipulação de algum animal. -/- -/- O SISTEMA ENDÓCRINO COMO UM SISTEMA DE COMUNICAÇÃO -/- O sistema endócrino é um sistema de comunicação que tem como objetivo coor-denar as funções das células de diferentes órgãos para mantença da homeostase do orga-nismo e promover seu desenvolvimento, crescimento e reprodução. Também ajuda os or-ganismos a adaptarem-se as mudanças de ambiente e ao habitat. O sistema endócrino representa um sistema de comunicação do tipo sem fio, diferentemente do sistema nervo-so que é um sistema de comunicação com fio. -/- Em todo o sistema de comunicação existe uma série de elementos que são necessá-rios para a realização da comunicação de forma efetiva. Esses elementos incluem o emis-sor, a mensagem, o sinal, o meio de transporte do sinal, o receptor, o efetor, a resposta e o feedback ou retroalimentação (figura 1). Todos os elementos são igualmente importan-tes e uma deficiência em qualquer deles pode interromper ou alterar a comunicação. -/- -/- Figura 1: componentes do sistema endócrino de comunicação. Fonte: ZARCO, 2018. -/- -/- Emissor ou transmissor -/- É o elemento responsável pela transmissão de uma mensagem; poderíamos com-pará-lo com a redação de notícias de um canal de televisão. Antes de decidir quais serão as notícias que serão transmitidas esse dia, em que ordem se apresentarão e que ênfase lhes darão, as pessoas da redação analisa rodas as informações disponíveis: provenientes de seus repórteres, de agências de notícias internacionais, publicada em jornais do dia, a existente na internet ou disponíveis através de redes sociais; isso significa que as mensa-gens transmitidas pelo emissor não são aleatórias, e sim respondem a uma análise respon-sável das necessidades de informação. -/- No sistema endócrino o emissor é a célula que produz e secreta um hormônio. Co-mo todo emissor responsável, a mesma célula analisa toda a informação relevante dispo-nível, tal como a concentração de diversos metabólitos no sangue, a concentração de ou-tros hormônios, e as mensagens que recebem por via nervosa, antes de decidir se secretará seu hormônio, em que quantidade o fará e com que frequência. Por essa razão, ao estudar o sistema endócrino não somente devemos conhecer a célula transmissora, e sim qual é a informação que a célula pode receber, e como a analisa e a prioriza para construir sua mensagem. -/- -/- Mensagem -/- É a informação transmitida pelo emissor. No caso de um sistema de notícias tele-visivas a mensagem é a notícia, por exemplo “Vaca dá a luz trigêmeos, um caso raro no Brasil”. No sistema endócrino a mensagem que se transmite é uma instrução para que em outra célula se realize determinadas ações. Por exemplo, os neurônios produtores de GnRH no hipotálamo de uma coelha, ao analisar as concentrações de estradiol circulantes e a informação nervosa procedente de neurônios sensoriais nós órgãos genitais da fêmea, podem “saber” que nos ovários existam folículos lisos para ovularem e que a coelha está copulando, pelo qual decidem transmitir a mensagem “Solicita-se os gonadotropos da adenohipófise a liberação de LH em quantidade suficiente para provocar a ovulação”. -/- -/- Sinal -/- É a forma a qual se codifica a mensagem para permitir sua difusão. No caso de um jornal, a mensagem (por exemplo a notícia da vaca que deu a luz trigêmeos) se codifi-ca em forma de ondas de rádio de uma determinada frequência, amplitude e intensidade; no caso do sistema endócrino a mensagem (a necessidade de realizar uma função celular) é codificada em forma de hormônio secretado em determinada quantidade, frequência e amplitude. Para o exemplo descrito supra, a mensagem se codifica na forma de uma grande elevação nas concentrações de GnRH no sangue do sistema porta hipotálamo-hipofisário. -/- É necessário tomar em conta que o emissor codifica a mensagem de forma tal que quando o receptor decifre o sinal obtenha a informação originalmente contida na mensa-gem. No entanto, o sinal pode ser interpretado de diferentes formas por receptores distintos, o que pode provocar respostas contrárias as esperadas. A notícia transmitida por um jornal de rádio, por exemplo, poderia estar codificada em forma de ondas de rádio que, casualmente, para o sistema eletrônico de um avião signifiquem “baixe a altitude e acelere”, razão pela qual é proibido utilizar aparelhos eletrônicos durante a decolagem e aterrissagem desses aparelhos. -/- Do mesmo modo, a mensagem codificada na forma de secreção de estradiol por parte dos ovários pode ser interpretado pelo sistema nervoso de uma ovelha como uma ordem para apresentar conduta de estro, pelas células do folículo ovariano como uma instrução para sofrer mitose e secretar o líquido folicular, pelos gonadotropos como uma ordem para a secreção de um pico pré-ovulatório de LH, e pelas células do endométrio como uma instrução para sintetizar receptores para a ocitocina. Dessa forma, o mesmo sinal (secreção de estradiol) pode conter diferentes mensagens para diferentes células do organismo. -/- Em alguns casos, pode-se apresentar uma resposta patológica devido as diversas formas de interpretação de uma mensagem, por exemplo, a repetição da secreção de adrenalina em um indivíduo estressado pode resultar no desenvolvimento de um proble-ma de hipertensão arterial. Por isso é necessário conhecer a maneira em que cada célula endócrina codifica suas mensagens, assim como a forma em que esses sinais podem ser interpretados em diferentes órgãos e tecidos, em diferentes momentos da vida do animal, em animais com diferentes antecedentes de espécies diferentes. -/- -/- Meio de transporte do sinal -/- O sinal tem que viajar ou difundir-se desde o emissor até o receptor, e em seu ca-minho pode ser modificado de diversas formas. Os sinais de rádio, por exemplo, viajam através da atmosfera e durante esse trajeto podem ser bloqueados por uma barreira física (como ocorre com as ondas de rádio AM em um túnel), ampliadas por uma estação repeti-dora, alteradas por um campo eletromagnético (uma aspiradora funcionando ao lado da sala de transmissão), entre outros. Da mesma forma, os sinais endócrinos que geralmente viajam no sangue, podem ser modificados ao longo do seu caminho. -/- A PGF₂α é inativada ao passar pelo pulmão, o angiotensinógeno é ativado pela re-nina na circulação, e a testosterona pode ser transformada em di-hidrotestosterona nas células da pele e na próstata, ou em estrógenos nos adipócitos e nos neurônios. Por tudo isso, o sinal que finalmente chega ao receptor pode ser diferente do transmitido pelo emissor. -/- Portanto, ao estudar qualquer sistema hormonal devemos conhecer as possíveis modificações que o hormônio pode sofrer desde o momento em que é secretado até que se uma ao seu receptor na célula branca. -/- -/- Receptor -/- É o elemento que recebe o sinal e interpreta a mensagem contida nele. No caso de um jornal de TV, o receptor é o canal correspondente (por exemplo o canal 2) em um aparelho de televisão. É importante ressaltar que um aparelho de TV possui muitos canais distintos, mas somente receberá mensagens se estiver ligado e sintonizado no canal que está transmitindo a mensagem de interesse. Ou seja, o receptor tem que estar ativo. -/- No caso das mensagens endócrinas os receptores são moléculas específicas nas células brancas. Essas moléculas são proteínas membranais ou citoplasmáticas (segundo o tipo de hormônio), que possui uma alta afinidade por seu hormônio, o que lhes permite registrar a mensagem apenas das baixíssimas concentrações em que os hormônios circu-lam. Os receptores possuem uma alta especificidade, o que significa que somente se unem a seu próprio hormônio, e não a outras substâncias. Em algumas ocasiões um receptor pode receber diversos hormônios do mesmo tipo; por exemplo o receptor de andrógenos pode unir testosterona, androstenediona, di-hidrotestosterona e diversos andrógenos sin-téticos. Apesar disso, cada um desses hormônios pode possuir uma afinidade diferente pelo receptor, pelo qual alguns serão mais potentes que outros para estimulação. -/- Em geral existe um número limitado de moléculas receptoras em cada célula, logo diz-se que os receptores são “saturáveis”, o qual significa que uma vez que todos sejam ocupados a célula não pode receber mais moléculas desse hormônio. Por essa razão a magnitude da resposta de um determinado hormônio vai aumentando conforme se aumen-tam suas concentrações, porém ao saturar-se os receptores alcançam um ponto em que a resposta já não aumenta embora sigam incrementando as concentrações hormonais já que os receptores não permanecem livres para unirem-se ao excesso de moléculas do hormô-nio. -/- As células, em contrapartida, podem regular tanto o número de receptores presen-tes como a afinidade destes por seu hormônio; isso significa que a magnitude da resposta antes um determinado sinal endócrino pode ser distinta em diferentes momentos da vida de um animal; depende do estado dos receptores presentes nos tecidos, pelo qual é impor-tante conhecer quais são os fatores que podem aumentar ou reduzir o número de recepto-res em uma célula, assim como aqueles que podem aumentar ou diminuir a afinidade des-ses receptores por seus hormônios. -/- -/- Efetor -/- É o elemento encarregado de responder a uma mensagem realizando uma ação, e é um elemento diferente do receptor. Vale ressaltar que no caso de uma transmissão de televisão o receptor é o aparelho sintonizado no canal de interesse, porém o efetor é o te-lespectador que está exposto as notícias. Esse telespectador sofrerá mudanças que podem resultar em uma ação. A mudança pode ser evidente (e auxiliar as vítimas de um desastre), ou simplesmente uma mudança potencial (ao se inteirar de uma notícia não se pode produ-zir nenhuma mudança aparente até que alguém lhe pergunte: já se interessou?, E nesse caso a resposta será: “sim” em lugar do “não”). Deve-se tomar em conta que o efetor pode estar ausente embora o receptor esteja presente (um televisor ligado em uma sala vazia). O efetor também pode estar inativado (o telespectador encontra-se dormindo); quando assim ocorre não irá produzir uma resposta embora o receptor esteja presente. -/- No sistema endócrino o efetor é, em geral, um sistema celular encarregado de rea-lizar uma determinada função. Na maioria dos casos trata-se de sistemas enzimáticos cuja função é estimulada pela união do hormônio ao seu receptor. Alguns hormônios, por exemplo, atuam através do sistema AMP cíclico (AMPc) logo, a união do hormônio ao seu receptor resulta na ativação de uma proteína chamada Proteína Gs, que ativa a enzima Adenil-ciclase (ou adenilato ciclase), a qual transforma ATP em AMPc. A presença de AMPc resulta na ativação de uma enzima cinese de proteínas que fosforiza outras enzi-mas, o que pode ativá-las ou inativá-las; nesses casos, é gerada uma cascata de eventos que resulta em uma mudança na atividade celular; por exemplo, a cadeia de eventos que produz-se em resposta ao AMPc quando a célula de Leydig do testículo é estimulada pela união do LH a seu receptor resulta na produção de testosterona, enquanto que a estimula-ção de um adipócito provocada pela união da adrenalina a seu receptor, que também atua através do sistema AMPc, resulta em uma série de eventos que provocam, finalmente, a liberação de ácidos graxos livres em direção a circulação. -/- Nos exemplos supra, o AMPc é considerado um mensageiro intracelular, já que o receptor capta o sinal (hormônio) no exterior da célula, o que resulta na produção de um novo sinal (mudança nas concentrações de AMPc) no interior da célula. Embora o sistema AMPc seja utilizado por muitos hormônios, não é um sistema universal; existem outros sistemas mensageiros intracelulares que também são utilizados para responder os hormô-nios que não entram nas células, por exemplo o sistema cálcio-calmodulina, ou os siste-mas baseados em receptores com atividade de cineses de tirosina. Nos casos que os hor-mônios possa atravessar livremente a membrana celular, como acontece com os hormôni-os esteroides, o hormônio se une a receptores presentes no citoplasma, que depois ingres-sam ao núcleo celular para intervir na regulação da transcrição do genoma. -/- De maneira independente ao mecanismo de ação de um determinado hormônio, sua presença finalmente desencadeará mudanças em um ou mais sistemas efetores da célula, o que permitirá que a mesma responda a mensagem que o emissor transmitiu originalmente. É evidente que para compreender a ação de qualquer hormônio é indispensável conhecer seu mecanismo de ação, o papel dos mensageiros intracelulares e as característi-cas dos sistemas efetores. Deve-se conhecer também quais são os fatores que afetam a transdução da mensagem já que uma célula pode regular seus sistemas efetores e dessa forma ter uma resposta maior, menor ou alterada ante a mesma mensagem. -/- -/- Resposta -/- Como mencionado, qualquer mensagem provoca uma resposta (embora somente seja potencial) sobre o efetor que a recebe. No sistema endócrino, as mensagens hormonais viajam constantemente pelo organismo e são captadas por todas as células que possuem receptores ativos para um determinado hormônio. Uma única célula pode ter receptores para diferentes hormônios, pelo qual pode estar recebendo diversas mensagens simultaneamente, e cada uma dessas mensagens pode afetar a resposta de outras mensagens. Por exemplo, a presença de progesterona pode alterar a resposta das células endometriais ao estradiol. Ademais, as células podem estar recebendo ao mesmo tempo uma informação não hormonal, como as concentrações de diversos metabólitos na circulação, ou a recebida pelo sistema nervoso. A célula analisa toda essa informação e com base nela decide se deve responder a mensagem hormonal que está recebendo como deve responder, com que intensidade e durante quanto tempo. A resposta final pode ser uma resposta física imediata (contração, secreção de um hormônio armazenado previa-mente), uma modificação bioquímica a curto prazo (síntese de um determinado hormônio ou outra substância), ou o início de uma série de mudanças que levam a uma mudança a longo prazo (divisão celular, diferenciação celular, crescimento, morte celular). -/- -/- Feedback ou retroalimentação -/- Quando em um sistema de comunicação se produz uma resposta, em muitos casos essa resposta engloba a geração de informação que vai retornar ao emissor, e que agora constituirá um ou mais dos elementos que o emissor tomará em conta antes de transmitir uma nova mensagem. Assim, se um jornal transmite uma mensagem “menina pobre necessita de doação de roupas”, a resposta de alguns efetores (telespectadores) que virão a doar roupas será conhecida pelo emissor, que assim saberá que já não será mais neces-sário voltar a transmitir a mensagem, o que o fará tomar a decisão de transmitir uma mensagem diferente como “menina pobre já não necessita de roupas, porém requer de ali-mentos para sua família”. Essa modificação da mensagem provocada pela resposta do efetor é conhecida como retroalimentação. -/- De forma análoga, no sistema endócrino a resposta da célula efetora geralmente é reconhecida pelo emissor, que em consequência modifica sua mensagem. Na maioria dos casos se produz uma retroalimentação negativa, que consiste em que a resposta do efetor provoca uma redução na intensidade da mensagem transmitida pelo emissor. Quando os gonadotropos de uma vaca secretam hormônio folículo estimulante (FSH), as células da granulosa de seus folículos ovarianos respondem realizando diversas funções, uma das quais é a secreção de inibina. A elevação nas concentrações circulantes de inibina é capta-da pelos gonadotropos, que logo sabem que o FSH já transmitiu sua mensagem, pelo que reduzem a secreção deste hormônio. A retroalimentação negativa é muito importante em qualquer sistema endócrino já que permite manter as concentrações hormonais dentro de limites aceitáveis. -/- A retroalimentação negativa pode ser de onda ultracurta, curta ou longa. A onda ultracurta é quando o hormônio produzido por uma célula pode inibir sua própria secre-ção. A retroalimentação negativa de onda curta é quando o hormônio produzido por uma célula pode inibir a de um órgão imediatamente superior na hierarquia (por exemplo, quando a progesterona produzida pelo corpo lúteo do ovário inibe a secreção de LH pelos gonadotropos da hipófise). O feedback negativo de onda longa sucede quando o hormônio produzido por uma célula inibe a uma célula de um órgão que está dois ou mais níveis por cima na escala hierárquica, por exemplo, quando a testosterona produzida pelas células de Leydig do testículo inibe diretamente os neurônios produtores de GnRH, saltando as células produtoras de LH e adenohipófise. -/- Existe também a retroalimentação positiva, da qual o primeiro hormônio estimula a secreção de um segundo hormônio, o que por sua vez estimula o primeiro, com o que se estabelece um círculo progressivo de estimulação. Um exemplo de retroalimentação positiva é a que se produz pouco antes da ovulação entre o LH hipofisário e o estradiol de origem folicular. Os dois hormônios se estimulam mutuamente até que alcancem níveis elevados de LH que provoca a ovulação. O círculo de feedback positivo termina quando o pico pré-ovulatório de LH mudanças sobre o folículo que incluem a perda da capacidade de produção de estrógenos. Todo o sistema de retroalimentação positiva deve ter um final abrupto sobre o qual se rompe o ciclo de estimulação mútua, já que não mais deverá ser produzida quantidades elevadas dos hormônios, até que todos os recursos do organismo sejam utilizados para esse fim. -/- -/- CLASSIFICAÇÃO QUÍMICA DOS HORMÔNIOS -/- Do ponto de vista químico e sobre o estudo da Fisiologia da Reprodução Animal, existem quatro grupos principais de hormônios: polipeptídios, esteroides, aminas e prostaglandinas; dentro de cada grupo, por sua vez, existem mais grupos de inúmeros outros hormônios dispostos em subdivisões. -/- -/- Hormônios polipeptídios -/- Os polipeptídios são cadeias de aminoácidos. Quando uma dessas cadeias está constituída por poucos aminoácidos é denominada simplesmente de polipeptídios, mas quando uma cadeia de aminoácidos é longa e adquire uma configuração espacial de três dimensões o polipeptídio é denominado proteína (figura 2). Muitos neurohormônios hipo-talâmicos são polipeptídios, como o liberador de gonadotropinas (GnRH), constituído por 10 aminoácidos, o hormônio liberador de tirotropina (TRH), formado por 3 aminoácidos, o somatostatina, constituído por 14 aminoácidos, a ocitocina que é formada por 8 aminoá-cidos etc. O sistema nervoso central e a hipófise produzem peptídeos opioides. -/- Entre os hormônios polipeptídios que por seu tamanho são considerados proteínas encontramos a prolactina, o hormônio do crescimento, os lactogênios placentários, a relaxina, a insulina e fatores de crescimento parecidos com a insulina (IGFs). Existe outro grupo de hormônios polipeptídios classificados como glicoproteínas. Trata-se de proteí-nas que possuem carboidratos unidos a alguns de seus aminoácidos. -/- -/- Figura 2: classificação dos hormônios polipeptídios. Fonte: ZARCO, 2018. -/- -/- Há um grupo de hormônios glicoproteicos que constituem uma família de molécu-las similares entre si, dentro das quais estão o hormônio luteinizante (LH), o hormônio folículo estimulante (FSH), o hormônio estimulante da tireoide (TSH), a gonadotropina coriônica humana (hCG) e a gonadotropina coriônica equina (eCG); todos estão formados pela subunidade alfa que é idêntica para os hormônios de uma determinada espécie animal, e por uma subunidade beta específica para cada hormônio. As duas subunidades mantém-se unidas através de ligações dissulfeto. Deve-se mencionar que os carboidratos associados as glicoproteínas podem ser distintos em diferentes idades, épocas do ano ou estados fisiológicos; esse processo é conhecido como microheterogenicidade, e recente-mente têm-se dado grande importância a seu estudo, já que é reconhecido fatores tais como a vida média de um hormônio ou sua atividade biológica podem ser modificados de acordo com o tipo de carboidratos presentes na molécula. -/- Existe outra família de hormônios glicoproteicos, que incluem a inibina A, a B, e a activina A, AB e B. Todos os hormônios polipeptídios possuem algumas características comuns. Em primeiro lugar, trata-se de moléculas hidrossolúveis que não conseguem atravessar as membranas celulares pelo qual se unem a receptores transmembranais que flutuam sobre a parede externa da membrana da célula branca e requerem de um segundo mensageiro intracelular, como o cálcio ou o AMPc, para levar sua mensagem ao interior da célula. -/- Os hormônios desse grupo, não podem ser administrados por via dérmica, oral, retal ou intravaginal, já que não podem atravessar a pela ou as mucosas intestinais, retais ou vaginais. Os polipeptídios são digeridos no estômago, o que também impede sua admi-nistração oral. Outra característica que deve-se tomar em conta é que as proteínas (embora não os polipeptídios pequenos) podem se desnaturalizar por fatores como o calor (são termolábeis), a congelação, ou mudanças de pH m a desnaturalização consiste em uma mudança na forma natural da proteína, o que leva a perda de sua função. Por essa razão, ao trabalhar com hormônios proteicos devem-se tomar cuidados especiais durante seu manejo para evitar a exposição a fatores desnaturalizantes. -/- -/- Hormônios esteroides -/- São moléculas derivadas do colesterol; a célula esteroidogênica pode sintetizar o colesterol, obtê-lo de reservas intracelulares ou da circulação. Na célula esteroidogênica existem diversas enzimas que atuam sequencialmente sobre a molécula de colesterol, provocando mudanças sucessivas até obter o hormônio final que será secretado, ao qual dependerá das enzimas que estão presentes e ativas na célula. -/- Existem cinco grupos principais de hormônios esteroides; os progestágenos, os estrógenos, os glicocorticoides e os mineralocorticoides (figura 3). -/- Os progestágenos são hormônios que favorecem o desenvolvimento da gestação; seus efeitos incluem, entre outros, a estimulação da secreção endometrial de substâncias nutritivas para o embrião, a estimulação do desenvolvimento embrionário e placentário, a inibição das contrações uterinas, bem como fazer com que a cérvix fique fechada. O principal hormônio natural desse grupo é a progesterona, mas existem uma grande quantidade de progestágenos sintéticos utilizados na medicina veterinária, tais como o acetato fluorogestona (FGA), o acetato de melengestrol (MGA), o altrenogest e o norgestomet. -/- Os estrógenos são os hormônios femininos responsáveis, entre outras funções, dos sinais do estro ou receptividade sexual nas fêmeas. A maior parte de seus efeitos estão no alcance da fertilização do ovócito. Os estrógenos, além de estimular a conduta sexual feminina, favorecem, entre outras coisas, a abertura da cérvix para permitir a passagem do espermatozoide, e as contrações uterinas para impulsionar o sêmen em direção aos ovidutos. O principal estrógeno natural é o estradiol 17β, outros membros naturais do grupo são a estrona, a equilina e a equilenina, esses dois últimos presentes exclusivamente em éguas gestantes. Também existem numerosos estrógenos sintéticos, tais como o valerato de estradiol, o benzoato de estradiol e o cipionato de estradiol. -/- Os andrógenos são hormônios masculinos. Possuem uma grande quantidade de efeitos encaminhados a alcançar o êxito reprodutivo do macho, como estimular a conduta sexual, estimular a produção de espermatozoides e estimular as secreções das glândulas sexuais acessórias. O andrógeno principal é a testosterona, outros andrógenos naturais incluem a androstenediona e a di-hidrotestosterona. Existe também inúmeros andrógenos sintéticos. -/- Os glicocorticoides ou corticosteroides possuem funções principalmente metabó-licas e de adaptação ao estresse. O principal corticosteroide na maioria das espécies é o cortisol, enquanto que nos ratos e outros roedores é a corticosterona. Na reprodução, os corticosteroides desempenham um papel relevante, em particular durante o parto e a lac-tação. -/- Os mineralocorticoides, como a aldotestosterona, se encarregam da regulação do balanço de líquidos e eletrólitos no organismo. -/- -/- Figura 3: subgrupos dos hormônios esteroides. Fonte: ZARCO, 2018. -/- -/- Os hormônios esteroides como grupos são hidrossolúveis, pelo qual podem atra-vessar livremente as membranas celulares, por essa razão utilizam receptores intracelula-res que se encontram no citoplasma da célula branca; também pode-se administrar por via oral, pela pele, e através das mucosas retal ou vaginal. São moléculas termoestáveis e não são digeridas no estômago, embora algumas possas sofrer modificações na pH ácido, alterando sua função. -/- -/- Aminas -/- São moléculas derivadas de um aminoácido que se modifica pela ação de enzimas específicas. Existem dois tipos de hormônios aminas: as catecolaminas e as indolaminas (figura 4). As catecolaminas derivam do aminoácido tirosina, e incluem a dopamina, a a-drenalina e a noradrenalina. As indolaminas derivam-se do triptofano, e incluem a seroto-nina e a melatonina. -/- As aminas são moléculas hidrossolúveis que não podem atravessar as membranas celulares e portanto atuam através de receptores membranais e segundos mensageiros intracelulares. -/- -/- Figura 4: classificação dos hormônios peptídicos. Fonte: ZARCO, 2018. -/- -/- Prostaglandinas -/- São substâncias derivadas do ácido araquidônico. A principal fonte desse ácido graxo são os fosfolipídios da membrana celular, a partir dos quais se podem liberar o ácido araquidônico mediante a ação da enzima fosfolipase A2. O ácido araquidônico se transforma em prostaglandina H mediante a ação da enzima ciclo-oxigenase (ou sintetase de prostaglandinas), que mais adiante se transforma em diferentes prostaglandinas especí-ficas pela ação de diversas enzimas. O tipo de prostaglandina produzido por cada célula dependerá do complemento de enzimas presentes. -/- A prostaglandina mais importante na reprodução é a PGF2α, a qual é responsável pela destruição do corpo lúteo na maioria das espécies; também provoca contrações uteri-nas, pelo qual é importante para o parto, e o transporte dos espermatozoides e a involução uterina depois do parto. Na prática veterinária a PGF2α natural (dinoprosr) ou seus seme-lhantes sintéticos (cloprostenol, luprostiol etc.) são utilizados para a sincronização do ciclo estral, para a indução do parto e para tratar diversas patologias. Outra prostaglandina com algumas ações relacionadas com a reprodução é a prostaglandina E2 (PGE2). -/- As prostaglandinas são substâncias anfipáticas (com propriedades hidrossolúveis e lipossolúveis), pelo qual podem atravessar as membranas celulares. -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- AUSTIN, Colin Russell; SHORT, R. Reproduction in mammals. 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